mRNA Splicing

Stable Identifier
R-HSA-72172
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
mRNA Splicing
Click the image above or here to open this pathway in the Pathway Browser
The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing. Most of the mRNA is spliced by the major pathway, involving the U1, U2, U4, U5 and U6 snRNPs. A minor fraction, about 1 %, of the mRNAs are spliced via the U12 dependent pathway.
Literature References
PubMed ID Title Journal Year
12226669 Comprehensive proteomic analysis of the human spliceosome.

Reed, R, Gygi, SP, Licklider, LJ, Zhou, Z

Nature 2002
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
RNA splicing (0008380)
Orthologous Events
mRNA Splicing (Bos taurus)
mRNA Splicing (Caenorhabditis elegans)
mRNA Splicing (Canis familiaris)
mRNA Splicing (Danio rerio)
mRNA Splicing (Dictyostelium discoideum)
mRNA Splicing (Drosophila melanogaster)
mRNA Splicing (Gallus gallus)
mRNA Splicing (Mus musculus)
mRNA Splicing (Plasmodium falciparum)
mRNA Splicing (Rattus norvegicus)
mRNA Splicing (Schizosaccharomyces pombe)
mRNA Splicing (Sus scrofa)
mRNA Splicing (Xenopus tropicalis)
Created
Krainer, AR  (2004-06-23)
Hastings, ML  (2004-06-23)
Cite Us!