Reactome | RPS11 [cytosol]

RPS11 [cytosol]

Stable Identifier

R-HSA-72327

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 11, P04643, 40S ribosomal protein S11

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62280 RPS11

Gene Names

RPS11

Chain

initiator methionine:, chain:2-158

Reference Genes

BioGPS Gene:6205 RPS11

COSMIC (genes):RPS11 RPS11

CTD Gene:6205 RPS11

dbSNP Gene:6205 RPS11

ENSEMBL:ENSG00000142534 RPS11

ENSEMBL_homo_sapiens_GENE:ENSG00000142534.7 RPS11

HGNC:10384 RPS11

KEGG Gene (Homo sapiens):6205 RPS11

Monarch:6205 RPS11

NCBI Gene:6205 RPS11

OMIM:180471 RPS11

UCSC:P62280 RPS11

Reference Transcript

RefSeq:NM_001015.4 RPS11

Other Identifiers

11715376_a_at

11745362_x_at

16864159

18671238

18671239

18671241

18671242

200031_PM_s_at

200031_s_at

32330_at

3439262

3439263

3838608

3838609

3838612

3838615

3838619

3838620

6205

7893727

7893956

7894634

7894999

7895762

8030368

GE78949

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0016020

GO:0019843

GO:0022626

GO:0022627

GO:0032040

GO:0042254

GO:0042274

GO:0043226

GO:0045202

GO:0070062

GO:1990904

PH_hs_0030181

TC19000735.hg

X06617_at

g4506680_3p_a_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS11 [nucleoplasm]

Inferred To

RPS11A [cytosol] (Saccharomyces cerevisiae)

RpS11 [cytosol] (Drosophila melanogaster)

rps1101 [cytosol] (Schizosaccharomyces pombe)

Rps11 [cytosol] (Mus musculus)

Rps11 [cytosol] (Rattus norvegicus)

rps-11 [cytosol] (Caenorhabditis elegans)

rps11 [cytosol] (Danio rerio)

rps11 [cytosol] (Dictyostelium discoideum)

rps11 [cytosol] (Xenopus tropicalis)

rps1102 [cytosol] (Schizosaccharomyces pombe)

cRPS11 [cytosol] (Gallus gallus)

RPS11 [cytosol] (Bos taurus)

RPS11 [cytosol] (Canis familiaris)

RPS11 [cytosol] (Plasmodium falciparum)

RPS11 [cytosol] (Sus scrofa)

Homologues of RPS11 [cytosol] (Saccharomyces cerevisiae)

Homologues of RPS11 [cytosol] (Schizosaccharomyces pombe)

RPS11B [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001006.1

OpenTargets

ENSG00000142534

HPA

ENSG00000142534-RPS11

GeneCards

P62280

Ensembl

ENST00000270625, ENSP00000270625, ENSG00000142534

PRO

P62280

Pharos - Targets

P62280

PDB

6ZVJ, 8Y0W, 6G5H, 6Z6L, 6OLG, 8IFD, 8G6J, 6G5I, 6Y57, 8Y0X, 6ZME, 6OLI, 6Z6M, 5VYC, 6ZP4, 6ZXF, 6G4S, 8PPK, 6ZUO, 6ZMI, 5LKS, 7XNX, 5T2C, 7A09, 7MQ8, 8G5Y, 6QZP, 6ZXH, 6ZV6, 8T4S, 8JDL, 6Z6N, 8G61, 6ZXG, 6ZOJ, 8IFE, 7QP7, 6ZMW, 7MQ9, 5A2Q, 6OLZ, 6Y2L, 7QP6, 7MQA, 8GLP, 7WTU, 6ZXD, 6ZVH, 5AJ0, 4UG0, 8OZ0, 6FEC, 7TQL, 6YBW, 6OLF, 6ZOK, 7R4X, 7WTT, 6ZN5, 6IP5, 8JDM, 6IP8, 6G18, 7WTV, 5OA3, 8PPL, 6IP6, 6G51, 6ZXE, 6G4W, 6XA1, 7K5I, 6ZON, 6G53, 7WTX, 4V6X, 8G60, 6ZM7, 8JDK, 6ZLW, 6ZMO, 7WTW, 6Y0G, 6OM0, 7XNY, 6OLE, 7WTZ, 7WU0, 5FLX, 7WTS, 8JDJ, 6ZMT, 6OM7

Interactors (47)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.642	5
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	4
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.564	2
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.564	3
UniProt:Q96BK5 PINX1			0.536	2
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.528	3
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.527	2
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:P25398 RPS12	2	RPS12 [nucleoplasm] (R-HSA-6798715) RPS12 [cytosol] (R-HSA-72329)	0.527	2
UniProt:P60866 RPS20	2	RPS20 [nucleoplasm] (R-HSA-6798727) RPS20 [cytosol] (R-HSA-72349)	0.527	2
UniProt:P62851 RPS25	2	RPS25 [nucleoplasm] (R-HSA-6798707) RPS25 [cytosol] (R-HSA-72357)	0.527	2
UniProt:P39019 RPS19	2	RPS19 [nucleoplasm] (R-HSA-6798710) RPS19 [cytosol] (R-HSA-72343)	0.527	2
UniProt:P62273 RPS29	2	RPS29 [nucleoplasm] (R-HSA-6798725) RPS29 [cytosol] (R-HSA-72367)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	7
UniProt:P08708 RPS17	2	RPS17 [nucleoplasm] (R-HSA-6798719) RPS17 [cytosol] (R-HSA-72339)	0.527	2
UniProt:Q96CT7 CC124			0.527	2
UniProt:P62263 RPS14	2	RPS14 [nucleoplasm] (R-HSA-6790669) RPS14 [cytosol] (R-HSA-72333)	0.527	2
UniProt:Q9BT73 PSMG3	1	PSMG3 [cytosol] (R-HSA-9908033)	0.527	2
UniProt:P62857 RPS28	2	RPS28 [nucleoplasm] (R-HSA-6791202) RPS28 [cytosol] (R-HSA-72365)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	3
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	4
UniProt:P61247 RPS3A	2	RPS3A [nucleoplasm] (R-HSA-6791182) RPS3A [cytosol] (R-HSA-72373)	0.527	2
UniProt:Q7Z478 DHX29			0.483	2
UniProt:Q86VM9 ZCH18			0.483	5
UniProt:Q9H4L4 SENP3	1	SENP3 [nucleoplasm] (R-HSA-2984296)	0.483	2
UniProt:P48634 PRC2A			0.483	2
UniProt:Q14444 CAPR1			0.483	2
UniProt:Q9BVJ6 UTP14A	1	UTP14A [nucleoplasm] (R-HSA-6790695)	0.483	2
UniProt:Q9Y520 PRC2C			0.483	2
UniProt:Q5JTH9 RRP12			0.483	2
UniProt:Q6P158 DHX57			0.483	2
UniProt:Q15650 TRIP4			0.483	2
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.483	2
UniProt:Q6PK04 CC137			0.483	2
UniProt:Q9H501 ESF1			0.483	2
UniProt:Q9NXV6 CARF			0.483	2
UniProt:Q8IUF8 MINA	1	RIOX2 [nucleoplasm] (R-HSA-8942439)	0.483	2
UniProt:P78316 NOP14	1	NOP14 [nucleoplasm] (R-HSA-6790710)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.483	2
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.483	3
UniProt:Q08J23 NSUN2	1	NSUN2 [nucleoplasm] (R-HSA-6782382)	0.483	2
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.483	2
UniProt:Q00005 2ABB			0.462	2
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.462	2

Cite Us!