Reactome | RPS2 [cytosol]

RPS2 [cytosol]

Stable Identifier

R-HSA-72347

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 2, P15880, 40S ribosomal protein S2, S4, LLREP3 protein

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Locations in the PathwayBrowser for interactor UniProt:Q96GM8 TOE1

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External Reference Information

External Reference

UniProt:P15880 RPS2

Gene Names

RPS2, RPS4

Chain

initiator methionine:, chain:2-293

Reference Genes

BioGPS Gene:6187 RPS2

COSMIC (genes):RPS2 RPS2

CTD Gene:6187 RPS2

dbSNP Gene:6187 RPS2

ENSEMBL:ENSG00000140988 RPS2

ENSEMBL_homo_sapiens_GENE:ENSG00000140988.16 RPS2

ENSEMBL_homo_sapiens_GENE:ENSG00000291931.1 RPS2

HGNC:10404 RPS2

KEGG Gene (Homo sapiens):6187 RPS2

Monarch:6187 RPS2

NCBI Gene:6187 RPS2

OMIM:603624 RPS2

UCSC:P15880 RPS2

Reference Transcript

RefSeq:NM_002952.3 RPS2

Other Identifiers

11756061_x_at

16822889

16822913

16822917

203107_3p_x_at

203107_PM_x_at

203107_x_at

212433_PM_x_at

212433_x_at

217466_PM_x_at

217466_x_at

221798_3p_x_at

221798_PM_x_at

221798_x_at

2331692

2331695

2335812

2363662

2373983

2414433

2475662

2491307

2785960

2785961

2787747

2907930

2954754

2954763

31527_at

3322248

3433833

3433834

3433835

3433836

3433837

3433838

3433839

3571878

3581198

3606530

3676302

3676303

3676304

3676308

3676309

3676310

3676313

3676318

3676322

3676324

3748826

3748828

3748829

3748830

3748831

3748832

3748833

3748834

3748836

3763019

3882787

3907385

3907388

4005753

4005754

6187

72997_f_at

7998655

8013348

8172154

89980_s_at

GO:0002181

GO:0003723

GO:0003729

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0015935

GO:0016020

GO:0017134

GO:0019899

GO:0022626

GO:0022627

GO:0036211

GO:0043226

GO:0045296

GO:0051443

GO:0070062

GO:1990904

HMNXSV003024132

Hs.182426.2.S1_3p_x_at

Hs.182426.3.A1_3p_a_at

Hs.182426.4.A1_3p_a_at

ILMN_1688749

ILMN_1737074

ILMN_2133360

ILMN_2218277

PH_hs_0030566

PH_hs_0039080

TC16000768.hg

TC17002540.hg

X17206_at

g4506718_3p_a_at

g4506718_3p_x_at

Participates

as an input of

PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

RPS2 [nucleoplasm]

Me2aR-RPS2 [cytosol]

Inferred To

AABR07029195.1 [cytosol] (Rattus norvegicus)

Rps2 [cytosol] (Mus musculus)

Rps2 [cytosol] (Rattus norvegicus)

LOC608162 [cytosol] (Canis familiaris)

rps-2 [cytosol] (Caenorhabditis elegans)

RPS2 [cytosol] (Bos taurus)

RPS2 [cytosol] (Gallus gallus)

RPS2 [cytosol] (Plasmodium falciparum)

RPS2 [cytosol] (Saccharomyces cerevisiae)

RPS2 [cytosol] (Sus scrofa)

RpS2 [cytosol] (Drosophila melanogaster)

rps2 [cytosol] (Danio rerio)

rps2 [cytosol] (Dictyostelium discoideum)

rps2 [cytosol] (Schizosaccharomyces pombe)

rps2 [cytosol] (Xenopus tropicalis)

Homologues of RPS2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_002943.2

OpenTargets

ENSG00000140988

GeneCards

P15880

HPA

ENSG00000140988-RPS2

Ensembl

ENST00000343262, ENSG00000140988, ENSP00000341885

PRO

P15880

Pharos - Targets

P15880

PDB

6IP6, 7WU0, 6ZUO, 8PPK, 7R4X, 6ZME, 7WTX, 8T4S, 7TQL, 8IFD, 6XA1, 6IP5, 5FLX, 5A2Q, 4UG0, 8G61, 6G4S, 6OM0, 6ZV6, 6ZMI, 6IP8, 6Y2L, 7WTZ, 6ZXH, 6ZMT, 6G53, 6Y57, 6OLE, 5T2C, 6Z6L, 8G5Y, 8JDK, 8G60, 6ZMO, 6G18, 8JDL, 7XNX, 6G51, 6OM7, 6OLF, 8IFE, 8G6J, 7WTV, 6ZMW, 7K5I, 6ZN5, 6Z6N, 7QP6, 6OLG, 6ZVJ, 6Z6M, 7XNY, 8JDJ, 8OZ0, 6ZVH, 8Y0W, 7A09, 6G5I, 7JQC, 6ZP4, 6YBD, 6OLI, 7JQB, 6ZXG, 6ZON, 8GLP, 6ZXF, 6G5H, 7QP7, 7WTW, 5AJ0, 8G5Z, 7QVP, 6QZP, 6OLZ, 8JDM, 6Y0G, 8Y0X, 5VYC, 5OA3, 6YBW, 8PPL, 6ZOK, 6ZXE, 4V6X, 5LKS, 6ZLW, 6ZOJ, 6ZXD, 6ZM7

Interactors (71)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60678 PRMT3	1	PRMT3 [cytosol] (R-HSA-8876692)	0.806	8
UniProt:Q9H0A0 NAT10	1	NAT10 [nucleoplasm] (R-HSA-6791008)	0.669	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.642	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:Q16342 PDCD2			0.623	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.615	4
UniProt:P46781 RPS9	2	RPS9 [nucleoplasm] (R-HSA-6790663) RPS9 [cytosol] (R-HSA-72387)	0.564	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.547	2
UniProt:P0DTD1-PRO_0000449619 REP			0.528	3
UniProt:Q8NFQ8 TOIP2			0.527	2
UniProt:Q6NSZ9 ZSCAN25	1	ZSCAN25 [nucleoplasm] (R-HSA-1247859)	0.527	3
UniProt:Q96QR8 PURB			0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.527	3
UniProt:P13693 TCTP			0.527	2
UniProt:P62269 RPS18	2	RPS18 [nucleoplasm] (R-HSA-6798701) RPS18 [cytosol] (R-HSA-72341)	0.527	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.527	3
UniProt:Q9NRM2 ZN277			0.527	3
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	3
UniProt:Q96NT1 NP1L5			0.527	2
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	3
UniProt:Q86TS9 MRPL52	1	MRPL52 [mitochondrial inner membrane] (R-HSA-5368187)	0.527	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.527	3
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q15050 RRS1			0.527	3
UniProt:P58557 YBEY			0.527	2
UniProt:Q02539 H1-1	1	HIST1H1A [nucleoplasm] (R-HSA-211245)	0.527	2
UniProt:O00566 MPHOSPH10	1	MPHOSPH10 [nucleoplasm] (R-HSA-6790661)	0.527	3
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.527	2
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:P08708 RPS17	2	RPS17 [nucleoplasm] (R-HSA-6798719) RPS17 [cytosol] (R-HSA-72339)	0.527	3
UniProt:P46783 RPS10	2	RPS10 [nucleoplasm] (R-HSA-6798733) RPS10 [cytosol] (R-HSA-72325)	0.527	3
UniProt:P46782 RPS5	2	RPS5 [nucleoplasm] (R-HSA-6791188) RPS5 [cytosol] (R-HSA-72379)	0.527	3
UniProt:P08865 RPSA	2	RPSA [nucleoplasm] (R-HSA-6798722) RPSA [cytosol] (R-HSA-72389)	0.527	3
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) Ub-48-RPS27A(1-76) [lysosomal membrane] (R-HSA-9763033) Ub-48-RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-9763012) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098)	0.527	2
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.527	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	3
UniProt:P62841 RPS15	2	RPS15 [nucleoplasm] (R-HSA-6798706) RPS15 [cytosol] (R-HSA-72335)	0.527	3
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.527	3
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.527	2
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.527	3
UniProt:Q9NXF1 TEX10	1	TEX10 [nucleoplasm] (R-HSA-3826589)	0.527	3
UniProt:Q5JTH9 RRP12			0.527	2
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.527	3
UniProt:P62750 RPL23A	1	RPL23A [cytosol] (R-HSA-72432)	0.527	3
UniProt:Q6P158 DHX57			0.527	3
UniProt:Q9ULX3 NOB1	2	NOB1 [nucleoplasm] (R-HSA-6791536) NOB1 [cytosol] (R-HSA-6791524)	0.527	2
UniProt:Q96GM8 TOE1			0.527	3
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	3
UniProt:O95793 STAU1			0.527	2
UniProt:Q5C9Z4 NOM1			0.527	2
UniProt:Q9BRP1 PDD2L			0.527	4
UniProt:Q9UII4 HERC5	1	HERC5 [cytosol] (R-HSA-936553)	0.527	2
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.527	2
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.527	2
UniProt:Q9Y2T7 YBOX2			0.527	3
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.527	3
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.527	2
UniProt:Q96GA3 LTV1	2	LTV1 [nucleoplasm] (R-HSA-6791566) LTV1 [cytosol] (R-HSA-6791520)	0.527	3
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.527	2
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	3
UniProt:P61247 RPS3A	2	RPS3A [nucleoplasm] (R-HSA-6791182) RPS3A [cytosol] (R-HSA-72373)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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