Reactome | RPS23 [cytosol]

RPS23 [cytosol]

Stable Identifier

R-HSA-72353

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 23, P39028, 40S ribosomal protein S23

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS23 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62266 RPS23

Gene Names

RPS23

Chain

initiator methionine:, chain:2-143

Reference Genes

BioGPS Gene:6228 RPS23

COSMIC (genes):RPS23 RPS23

CTD Gene:6228 RPS23

dbSNP Gene:6228 RPS23

ENSEMBL:ENSG00000186468 RPS23

ENSEMBL_homo_sapiens_GENE:ENSG00000186468.13 RPS23

HGNC:10410 RPS23

KEGG Gene (Homo sapiens):6228 RPS23

Monarch:6228 RPS23

NCBI Gene:6228 RPS23

OMIM:603683 RPS23

UCSC:P62266 RPS23

Reference Transcript

RefSeq:NM_001025.4 RPS23

Other Identifiers

11719782_a_at

11719783_at

11719784_x_at

16997751

200926_PM_at

200926_at

227722_PM_at

227722_at

2367246

2744238

2831286

2865052

2865053

2865054

2865055

2865056

2865057

2865058

2865059

2865060

2865061

2865062

2865063

2865064

2865065

2865068

2865071

2865072

2865073

2865077

347_s_at

3980725

3980726

50961_at

6228

74562_f_at

8112961

A_33_P3257714

D14530_at

GE57529

GE80974

GE86226

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0006412

GO:0015935

GO:0016020

GO:0022626

GO:0022627

GO:0032040

GO:0034063

GO:0042254

GO:0042274

GO:0043226

GO:0045202

GO:1990145

GO:1990904

HMNXSV003025193

Hs.107187.2.S1_3p_at

ILMN_1652073

ILMN_1772459

PH_hs_0029995

TC05001547.hg

g4506700_3p_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

3OHP62-RPS23 [nucleoplasm]

RPS23 [nucleoplasm]

Inferred To

Homologues of RPS23 [cytosol] (Saccharomyces cerevisiae)

Homologues of RPS23 [cytosol] (Schizosaccharomyces pombe)

Homologues of RPS23 [cytosol] (Sus scrofa)

RPS23B [cytosol] (Saccharomyces cerevisiae)

Rps23 [cytosol] (Mus musculus)

Rps23 [cytosol] (Rattus norvegicus)

RpS23 [cytosol] (Drosophila melanogaster)

rps23 [cytosol] (Danio rerio)

rps23 [cytosol] (Dictyostelium discoideum)

rps23 [cytosol] (Schizosaccharomyces pombe)

rps23 [cytosol] (Xenopus tropicalis)

rps-23 [cytosol] (Caenorhabditis elegans)

rps2302 [cytosol] (Schizosaccharomyces pombe)

RPS23 [cytosol] (Bos taurus)

RPS23 [cytosol] (Canis familiaris)

RPS23 [cytosol] (Gallus gallus)

RPS23 [cytosol] (Plasmodium falciparum)

RPS23 [cytosol] (Sus scrofa)

RPS23A [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001016.1

OpenTargets

ENSG00000186468

GeneCards

P62266

HPA

ENSG00000186468-RPS23

Ensembl

ENST00000651545, ENSG00000186468, ENSP00000296674, ENSP00000498621, ENST00000296674

PRO

P62266

Pharos - Targets

P62266

PDB

6FEC, 6XA1, 6G5H, 8Y0W, 6ZVJ, 7WTS, 5AJ0, 8JDM, 7XNX, 6OLE, 6ZME, 8T4S, 6ZVH, 7WTZ, 6ZLW, 6ZM7, 6G5I, 7WTX, 6ZXH, 4UG0, 8JDL, 6ZOJ, 4CXG, 6ZOK, 6ZV6, 6Y57, 6G4W, 6Z6L, 7A09, 6ZMO, 8JDJ, 5VYC, 6ZXG, 6ZMT, 4CXH, 7XNY, 6ZMI, 8Y0X, 6Y2L, 6ZUO, 8OZ0, 6OM7, 6IP5, 6OLG, 6ZXE, 6OLF, 6ZON, 7QP6, 6IP8, 6G4S, 6Z6M, 6IP6, 7K5I, 6Z6N, 5OA3, 6Y0G, 6ZXD, 6OLI, 6ZMW, 6ZN5, 7WU0, 8JDK, 7WTW, 6YBW, 8IFE, 6OM0, 7WTV, 6OLZ, 6G51, 7MQA, 5LKS, 6G18, 5T2C, 6QZP, 7WTU, 5FLX, 5A2Q, 6ZP4, 7WTT, 7TQL, 4V6X, 6G53, 6ZXF, 7MQ8, 7R4X, 7QP7, 8IFD, 7MQ9

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.564	2
UniProt:Q8N543 OGFOD1	1	OGFOD1 [nucleoplasm] (R-HSA-2980928)	0.556	3
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.525	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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