Reactome | RPS24 [cytosol]

RPS24 [cytosol]

Stable Identifier

R-HSA-72355

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 24, P16632, 40S ribosomal protein S24, S19

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS24 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62847 RPS24

Gene Names

RPS24

Chain

chain:1-133

Reference Genes

BioGPS Gene:6229 RPS24

COSMIC (genes):RPS24 RPS24

CTD Gene:6229 RPS24

dbSNP Gene:6229 RPS24

ENSEMBL:ENSG00000138326 RPS24

HGNC:10411 RPS24

KEGG:hsa:6229 RPS24

Monarch:6229 RPS24

NCBI Gene:6229 RPS24

OMIM:602412 RPS24

UCSC:P62847 RPS24

Reference Transcript

Other Identifiers

11740590_at

11757021_x_at

1555878_3p_at

1555878_PM_at

1555878_at

16656389

16656391

16656393

16656395

16656397

16656399

16656401

16656403

16656405

16656407

16656409

16656411

16656413

16656415

16656417

16656419

16656421

16656423

16656433

16706412

18670719

18670720

18670721

18670722

18670723

18670724

18670725

18670726

18670727

18670728

18670729

18670730

18670731

18670732

200061_PM_s_at

200061_s_at

32315_at

3253439

3253440

3253441

3253442

3253443

3253444

3253445

3253446

3253447

3253448

3253449

3253450

3253451

3253452

3253453

3253456

3253457

3253459

3253461

3253463

3253464

6229

64287_s_at

78185_at

7892516

7894061

7894214

7895026

7895622

7895687

7895833

7895998

7928551

A_14_P130196

A_19_P00804723

A_23_P1206

GE711672

GE79478

GE86528

GO:0002181

GO:0002376

GO:0003723

GO:0003735

GO:0005198

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0015935

GO:0016020

GO:0022626

GO:0022627

GO:0031369

GO:0032040

GO:0034101

GO:0042274

GO:0043226

GO:0044391

GO:1990904

HMNXSV003003724

HMNXSV003022039

HMNXSV003046110

Hs2.377298.1.A1_3p_a_at

Hs2.377298.1.A1_3p_at

ILMN_1656625

ILMN_2399893

M31520_at

PH_hs_0029876

PH_hs_0035832

g12653502_3p_s_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS24 [nucleoplasm]

Inferred To

Ghost homologue of RPS24 [cytosol] (Danio rerio)

LOC119881401 [cytosol] (Canis familiaris)

RPS24 [cytosol] (Bos taurus)

RPS24 [cytosol] (Gallus gallus)

RPS24 [cytosol] (Plasmodium falciparum)

RPS24 [cytosol] (Sus scrofa)

RPS24B [cytosol] (Saccharomyces cerevisiae)

rps2401 [cytosol] (Schizosaccharomyces pombe)

rps2402 [cytosol] (Schizosaccharomyces pombe)

rps-24 [cytosol] (Caenorhabditis elegans)

rps24 [cytosol] (Dictyostelium discoideum)

rps24 [cytosol] (Xenopus tropicalis)

Homologues of RPS24 [cytosol] (Saccharomyces cerevisiae)

Homologues of RPS24 [cytosol] (Schizosaccharomyces pombe)

RPS24A [cytosol] (Saccharomyces cerevisiae)

RpS24 [cytosol] (Drosophila melanogaster)

Rps24 [cytosol] (Mus musculus)

Rps24 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_148982.1, NP_001135755.1, NP_001017.1, NP_001135757.1

OpenTargets

ENSG00000138326

ENSEMBL

ENST00000613865, ENSP00000494231, ENSP00000478869, ENST00000440692, ENST00000464716, ENSP00000361435, ENST00000372360, ENSP00000414321

HPA

ENSG00000138326-RPS24

PRO

P62847

Pharos - Targets

P62847

Orphanet

RPS24

GlyGen

P62847

PDB

7QP6, 6Y0G, 8JDM, 4V6X, 6ZLW, 8G5Y, 5A2Q, 7XNX, 6ZMI, 6OM7, 4UG0, 7WTX, 8IFD, 6Z6L, 7MQA, 5T2C, 6ZXD, 5FLX, 6ZON, 8XXN, 7WU0, 8XXL, 6ZXF, 7WTS, 6IP8, 6ZOK, 8Y0X, 6YBW, 8G61, 8JDL, 6OLE, 7WTU, 8QOI, 6ZN5, 6MTE, 8G6J, 7WTV, 7QVP, 6MTD, 6Z6M, 6QZP, 6ZXE, 6ZME, 8PPL, 6OM0, 8OZ0, 6XA1, 6G5H, 5AJ0, 8G60, 8JDK, 6IP5, 6OLF, 8T4S, 6ZMT, 7WTT, 6ZVH, 6ZMW, 6G53, 6G4W, 6ZOJ, 6ZV6, 7R4X, 8XXM, 6ZP4, 6ZM7, 8G5Z, 7MQ9, 6ZXG, 7MQ8, 6G5I, 7QP7, 6ZMO, 6OLG, 6FEC, 6IP6, 8Y0W, 8JDJ, 8PPK, 7WTW, 5VYC, 6OLZ, 8IFE, 5LKS, 6G18, 7WTZ, 6G4S, 6G51, 6Z6N, 7XNY, 5OA3, 7K5I, 6Y57, 6OLI, 6Y2L, 6ZXH, 8GLP, 7TQL, 6ZUO

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	7
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	2
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.527	2
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	2
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	2

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