Reactome | RPS28 [cytosol]

RPS28 [cytosol]

Stable Identifier

R-HSA-72365

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 28, P25112, 40S ribosomal protein S28

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS28 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62857 RPS28

Gene Names

RPS28

Chain

chain:1-69

Reference Genes

BioGPS Gene:6234 RPS28

COSMIC (genes):RPS28 RPS28

CTD Gene:6234 RPS28

dbSNP Gene:6234 RPS28

ENSEMBL:ENSG00000233927 RPS28

HGNC:10418 RPS28

KEGG:hsa:6234 RPS28

Monarch:6234 RPS28

NCBI Gene:6234 RPS28

OMIM:603685 RPS28

UCSC:P62857 RPS28

Reference Transcript

RefSeq:NM_001031.4 RPS28

Other Identifiers

11742666_s_at

11742667_x_at

11757387_x_at

11759537_a_at

11759538_at

11761031_x_at

11763284_a_at

16729548

16857878

208902_PM_s_at

208902_s_at

208903_PM_at

208903_at

208904_PM_s_at

208904_s_at

2531815

2531816

2531817

3342374

3342375

3342376

3342377

3713452

3713453

3819460

3819461

3819462

3819463

3819464

3819465

3819466

3819467

39798_at

48357_at

6234

7942824

8005471

8025395

A_14_P135680

A_24_P40010

A_33_P3282836

GE54648

GE85004

GO:0000028

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0015935

GO:0022627

GO:0030490

GO:0032040

GO:0042254

GO:0042274

GO:0043226

GO:0045202

GO:0065003

GO:0070062

GO:0098556

GO:1990904

HMNXSV003031681

Hs.153177.1.A2_3p_at

ILMN_1651228

ILMN_1684258

PH_hs_0031869

TC19000146.hg

U58682_at

g12653172_3p_a_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS28 [nucleoplasm]

Inferred To

rps2802 [cytosol] (Schizosaccharomyces pombe)

RPS28 [cytosol] (Bos taurus)

RPS28 [cytosol] (Canis familiaris)

RPS28 [cytosol] (Gallus gallus)

RPS28 [cytosol] (Plasmodium falciparum)

RPS28 [cytosol] (Sus scrofa)

Rps28 [cytosol] (Mus musculus)

Rps28 [cytosol] (Rattus norvegicus)

rps-28 [cytosol] (Caenorhabditis elegans)

Homologues of RPS28 [cytosol] (Schizosaccharomyces pombe)

rps2801 [cytosol] (Schizosaccharomyces pombe)

RPS28B [cytosol] (Saccharomyces cerevisiae)

rps28 [cytosol] (Danio rerio)

rps28 [cytosol] (Dictyostelium discoideum)

rps28 [cytosol] (Xenopus tropicalis)

RpS28b [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001022.1

OpenTargets

ENSG00000233927

ENSEMBL

ENSP00000472469, ENST00000600659

HPA

ENSG00000233927-RPS28

PRO

P62857

Pharos - Targets

P62857

Orphanet

RPS28

GlyGen

P62857

PDB

6IP5, 7QP7, 4V6X, 8G5Y, 6ZOJ, 6ZVJ, 6Y0G, 7XNY, 6G51, 6OLZ, 7WTZ, 8T4S, 5LKS, 7WTW, 5VYC, 7R4X, 5OA3, 6ZXG, 7MQ9, 8XXN, 7A09, 6ZP4, 6FEC, 5A2Q, 8JDM, 8XXL, 6IP6, 6OLE, 8JDL, 8G61, 6ZMO, 7QP6, 7MQA, 8IFD, 6Z6N, 6ZMI, 7XNX, 4UG0, 6G18, 6OM7, 7K5I, 6ZXH, 5T2C, 7TQL, 7MQ8, 8GLP, 6Y57, 6ZLW, 6Y2L, 8Y0X, 6OM0, 8PPL, 6OLF, 6G4W, 6ZVH, 6Z6L, 6ZN5, 7WTX, 7WTV, 8G6J, 7WTU, 6QZP, 6ZUO, 6ZXF, 8XXM, 6G5H, 8G5Z, 5FLX, 6ZXD, 8JDK, 8G60, 6YBS, 8OZ0, 6ZON, 7WU0, 6IP8, 8Y0W, 6ZOL, 8JDJ, 8PPK, 6G4S, 6Z6M, 6ZMT, 6ZMW, 6G53, 8IFE, 6ZV6, 7WTT, 8QOI, 6OLI, 6ZME, 5AJ0, 6G5I, 6OLG, 6XA1, 6ZM7, 6ZXE

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.715	4
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:P0C7H8 KRTAP2-3	1	KRTAP2-3 [cytosol] (R-HSA-6809959)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:O95273 CCDB1			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:P26583 HMGB2	1	HMGB2 [nucleoplasm] (R-HSA-266211)	0.547	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q15599 NHRF2			0.508	2

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