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About
What is Reactome ?
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Digital Preservation
Contact us
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Table of Contents
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RPS4X [cytosol]
Stable Identifier
R-HSA-72375
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
40S small ribosomal protein 4, P12750, 40S ribosomal protein S4, X isoform, Single copy abundant mRNA protein, SCR10
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
IMPACT binds GCN1 (Homo sapiens)
GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
Viral mRNA Translation (Homo sapiens)
Synthesis of PB1-F2 (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Viral Protein Synthesis (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 modulates host translation machinery (Homo sapiens)
SARS-CoV-1 nsp1 binds to 40S ribosomal subunit (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
40S ribosomal complex:nsp1 [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 modulates host translation machinery (Homo sapiens)
SARS-CoV-2 nsp1 binds to 40S ribosomal complex (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
40S ribosomal complex:nsp1 [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Selenocysteine synthesis (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Elongation (Homo sapiens)
Peptide chain elongation (Homo sapiens)
Aminoacyl-tRNA binds to the ribosome at the A-site (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Hydrolysis of eEF1A:GTP (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
Release of 40S and 60S subunits from the 80S ribosome (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
The 60S subunit joins the translation initiation complex (Homo sapiens)
40S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
40S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
eIF5B:GTP is hydrolyzed and released (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:tRNA Complex [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)
cleaved polypeptide:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:cleaved polypeptide [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S ribosome [cytosol] (Homo sapiens)
40S ribosomal complex [cytosol] (Homo sapiens)
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
RPS4X [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62701 RPS4X
Gene Names
RPS4X, CCG2, RPS4, SCAR
Chain
initiator methionine:, chain:2-263
Reference Genes
BioGPS Gene:6191 RPS4X
COSMIC (genes):RPS4X RPS4X
CTD Gene:6191 RPS4X
dbSNP Gene:6191 RPS4X
ENSEMBL:ENSG00000198034 RPS4X
ENSEMBL_homo_sapiens_GENE:ENSG00000198034.11 RPS4X
HGNC:10424 RPS4X
KEGG Gene (Homo sapiens):6191 RPS4X
Monarch:6191 RPS4X
NCBI Gene:6191 RPS4X
OMIM:312760 RPS4X
UCSC:P62701 RPS4X
Reference Transcript
RefSeq:NM_001007.4 RPS4X
Other Identifiers
11757780_x_at
17112005
200933_3p_x_at
200933_PM_x_at
200933_x_at
213347_3p_x_at
213347_PM_x_at
213347_x_at
2806954
3373987
3373989
34643_at
3467630
4012157
4012158
4012159
4012160
4012162
4012163
4012165
4012168
4012169
4012170
4012171
4012172
4012173
6191
8173513
GO:0002181
GO:0003723
GO:0003735
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005840
GO:0005925
GO:0006412
GO:0008284
GO:0015935
GO:0016020
GO:0019843
GO:0022626
GO:0022627
GO:0032040
GO:0036464
GO:0042254
GO:0042274
GO:0043226
GO:0045202
GO:0045727
GO:0070062
GO:1990904
HMNXSV003044761
Hs.108124.5.A1_3p_a_at
Hs.108124.5.A1_3p_x_at
ILMN_1810577
ILMN_2166831
PH_hs_0030329
TC0X001138.hg
g4506724_3p_a_at
Participates
as a member of
RPS4X,RPS4Y1,RPS4Y2 [cytosol] (Homo sapiens)
Other forms of this molecule
RPS4X [nucleoplasm]
Inferred To
rps-4 [cytosol]
(Caenorhabditis elegans)
rps402 [cytosol]
(Schizosaccharomyces pombe)
RPS4X [cytosol]
(Canis familiaris)
RPS4X [cytosol]
(Plasmodium falciparum)
RPS4X [cytosol]
(Sus scrofa)
Rps4x [cytosol]
(Mus musculus)
Rps4x [cytosol]
(Rattus norvegicus)
RPS4B [cytosol]
(Saccharomyces cerevisiae)
rps401 [cytosol]
(Schizosaccharomyces pombe)
rps4 [cytosol]
(Dictyostelium discoideum)
rps4 [cytosol]
(Xenopus tropicalis)
RPS4 [cytosol]
(Bos taurus)
RPS4 [cytosol]
(Gallus gallus)
rps4x [cytosol]
(Danio rerio)
Homologues of RPS4X [cytosol]
(Saccharomyces cerevisiae)
Homologues of RPS4X [cytosol]
(Schizosaccharomyces pombe)
RPS4A [cytosol]
(Saccharomyces cerevisiae)
RpS4 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000998.1
OpenTargets
ENSG00000198034
HPA
ENSG00000198034-RPS4X
GeneCards
P62701
Ensembl
ENST00000316084
,
ENSG00000198034
,
ENSP00000362744
PRO
P62701
Pharos - Targets
P62701
PDB
6ZVH
,
6ZM7
,
6ZOJ
,
6ZVJ
,
8IFD
,
7K5I
,
7A09
,
6ZOK
,
6YBW
,
6OM7
,
8Y0X
,
8Y0W
,
8G6J
,
8IFE
,
6G53
,
7XNX
,
7XNY
,
7WTS
,
8OZ0
,
6ZUO
,
6ZME
,
7WTT
,
6G51
,
6ZP4
,
7MQ8
,
6QZP
,
6IP8
,
5VYC
,
6OM0
,
7TQL
,
6G4S
,
6ZXH
,
7R4X
,
6IP6
,
8JDL
,
6FEC
,
7MQA
,
6IP5
,
8T4S
,
8JDM
,
7WTX
,
6Z6L
,
6ZLW
,
8GLP
,
7WTZ
,
7WU0
,
6Y57
,
8PPK
,
8PPL
,
6ZMW
,
6ZXD
,
6ZN5
,
6ZXE
,
6Z6N
,
4V6X
,
7QP6
,
6Y2L
,
6ZON
,
6ZXF
,
6ZXG
,
7QP7
,
6G4W
,
6Y0G
,
8JDJ
,
5T2C
,
5LKS
,
6G18
,
6ZMI
,
6ZV6
,
4UG0
,
7WTU
,
8G61
,
6OLI
,
7WTV
,
8G5Y
,
8G60
,
5OA3
,
8JDK
,
6G5I
,
6G5H
,
6XA1
,
6ZMO
,
7QVP
,
7WTW
,
6OLF
,
6Z6M
,
5A2Q
,
6OLE
,
6ZMT
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.69
4
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.643
5
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.638
3
UniProt:P06307 CCK
1
CCK [extracellular region]
(R-HSA-388539)
0.556
3
UniProt:P02545 LMNA
3
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.556
3
UniProt:Q01658 DR1
1
DR1 [nucleoplasm]
(R-HSA-3662280)
0.556
3
UniProt:Q14957 GRIN2C
3
GRIN2C [plasma membrane]
(R-HSA-419560)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:Q00403 GTF2B
1
GTF2B [nucleoplasm]
(R-HSA-65888)
0.556
3
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.556
3
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
2
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