Reactome | RPL13A [cytosol]

RPL13A [cytosol]

Stable Identifier

R-HSA-72412

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L13a, 23 kDa highly basic protein

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P40429 RPL13A

Gene Names

RPL13A

Chain

initiator methionine:, chain:2-203

Reference Genes

BioGPS Gene:23521 RPL13A

COSMIC (genes):RPL13A RPL13A

CTD Gene:23521 RPL13A

dbSNP Gene:23521 RPL13A

ENSEMBL:ENSG00000142541 RPL13A

HGNC:10304 RPL13A

KEGG:hsa:23521 RPL13A

Monarch:23521 RPL13A

NCBI Gene:23521 RPL13A

OMIM:619225 RPL13A

UCSC:P40429 RPL13A

Reference Transcript

Other Identifiers

11755250_x_at

11757331_x_at

11757385_x_at

11761278_at

16707927

16864141

17119144

17119146

17119148

17119150

200715_PM_x_at

200715_x_at

200716_PM_x_at

200716_x_at

210646_PM_x_at

210646_x_at

211942_3p_x_at

211942_PM_x_at

211942_x_at

212790_PM_x_at

212790_x_at

23521

2865355

2865361

3017977

3141962

3259616

3259618

3259619

3405583

3449689

3449690

3449692

35119_at

3515420

3515421

3537038

3562984

3838576

3838579

3838580

3838581

3838582

3838583

3838584

3838585

3838586

3838587

3838588

3838589

3838590

3838591

3838592

3838593

3838594

3838595

3838596

3838597

3838598

3838599

3838600

3838601

3838602

3838603

3838604

3916472

3916474

3916475

3957510

8030351

8030360

8030362

8030364

8030366

A_21_P0000218

A_21_P0000219

A_21_P0000220

A_21_P0000221

A_23_P90143

GE81797

GO:0002181

GO:0002376

GO:0003723

GO:0003729

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0006417

GO:0015934

GO:0016020

GO:0017148

GO:0022625

GO:0022626

GO:0032496

GO:0042592

GO:0043226

GO:0045202

GO:0048246

GO:0048870

GO:0060425

GO:0071346

GO:0097452

GO:1901194

GO:1990904

HMNXSV003005260

HMNXSV003026143

HMNXSV003026944

HMNXSV003027111

HMNXSV003031267

ILMN_1667609

ILMN_1682354

ILMN_1713369

ILMN_1743217

ILMN_2165762

PH_hs_0030383

PH_hs_0033702

RNA33606|snoRNA_scaRNA_202_86

RNA33616|snoRNA_scaRNA_212_83

RNA33674|snoRNA_scaRNA_270_77

RNA33776|snoRNA_scaRNA_372_66

TC19002198.hg

TC19002606.hg

X56932_at

g12653484_3p_s_at

g12804528_3p_x_at

Participates

as an input of

INF-gamma induced phosphorylation of L13a (Homo sapiens)

as an output of

Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)

as a component of

60S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

p-RPL13A [cytosol]

Inferred To

rpl-13A [cytosol] (Caenorhabditis elegans)

rpl1601 [cytosol] (Schizosaccharomyces pombe)

Homologues of RPL13A [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of RPL13A [cytosol] (Gallus gallus)

rpl13a [cytosol] (Danio rerio)

rpl13a [cytosol] (Dictyostelium discoideum)

rpl13a [cytosol] (Xenopus tropicalis)

RPL16A [cytosol] (Saccharomyces cerevisiae)

RPL13A [cytosol] (Bos taurus)

RPL13A [cytosol] (Canis familiaris)

RPL13A [cytosol] (Plasmodium falciparum)

RPL13A [cytosol] (Sus scrofa)

rpl1602 [cytosol] (Schizosaccharomyces pombe)

Rpl13a [cytosol] (Mus musculus)

Rpl13a [cytosol] (Rattus norvegicus)

RpL13A [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000142541

ENSEMBL

ENSG00000142541, ENSP00000375730, ENST00000391857

GeneCards

RPL13A

HPA

ENSG00000142541-RPL13A

PRO

P40429

Pharos - Targets

P40429

GlyGen

P40429

PDB

8FKZ, 8G6J, 6IP5, 8FLB, 8FKT, 8XSX, 8FL6, 9G8M, 8QFD, 6Y0G, 6LU8, 8G61, 8IPY, 8FL2, 8JDK, 8K2C, 6Y2L, 6XA1, 8Y0X, 6OLE, 8INK, 8IPX, 8OJ8, 9GMO, 6Z6N, 6IP6, 8IR1, 8FKQ, 8FLA, 7XNY, 8IFE, 5LKS, 8FKV, 4UG0, 8IR3, 8FKW, 8IDY, 8YOP, 8A3D, 8IPD, 8IDT, 6LQM, 8FL4, 8G60, 8FLC, 6OLF, 8JDJ, 6OLI, 6LSS, 6Z6L, 8OHD, 8IFD, 8FLD, 8INE, 8FKR, 8XSZ, 8IE3, 8FL7, 8FKP, 8FKX, 6Y57, 6IP8, 6OLZ, 7QVP, 6ZM7, 6Y6X, 8Y0W, 5AJ0, 8JDM, 8G5Z, 8G5Y, 8OJ0, 6ZMI, 7OW7, 6LSR, 5T2C, 7XNX, 8XSY, 8FLE, 6OM7, 8FKY, 8FKS, 8FKU, 8YOO, 8FL9, 7BHP, 8FL0, 8FLF, 8FL3, 8GLP, 4V6X, 6OLG, 6W6L, 6ZME, 8JDL, 6ZMO, 8INF, 6OM0, 6Z6M, 6QZP, 8QOI, 7F5S, 8OJ5

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.643	5
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.643	3
UniProt:Q15050 RRS1			0.643	4
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.643	4
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P06428 VE6			0.547	2
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.547	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.527	2
UniProt:Q6DKI1 RL7L			0.527	4
UniProt:O60783 MRPS14	1	MRPS14 [mitochondrial inner membrane] (R-HSA-5368192)	0.527	3
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.527	4
UniProt:O75607 NPM3			0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:Q9UEG4 ZN629			0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:O15381 NVL			0.527	2
UniProt:Q8IYB3 SRRM1	2	SRRM1 [cytosol] (R-HSA-159255) SRRM1 [nucleoplasm] (R-HSA-156781)	0.527	3
UniProt:Q9BYC9 MRPL20	1	MRPL20 [mitochondrial inner membrane] (R-HSA-5368243)	0.527	2
UniProt:Q15397 PUM3			0.527	3
UniProt:Q9BWC9 CC106			0.527	2
UniProt:Q9H6S0 YTHDC2	1	YTHDC2 [nucleoplasm] (R-HSA-9935827)	0.527	3
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.527	2
UniProt:Q14684 RRP1B			0.527	2
UniProt:P49406 MRPL19	1	MRPL19 [mitochondrial inner membrane] (R-HSA-5368215)	0.527	2
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.527	2
UniProt:Q14146 URB2			0.527	3
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:Q96K80 ZC3HA			0.527	2
UniProt:Q8N9T8 KRI1			0.527	2
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.527	2
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.527	2
UniProt:Q9GZR2 REXO4			0.527	4
UniProt:Q7L3S4 ZNF771	1	ZNF771 [nucleoplasm] (R-HSA-3110226)	0.527	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.527	2
UniProt:Q96PV6 LENG8			0.527	2
UniProt:Q15020 SART3			0.527	3
UniProt:P42696 RBM34			0.527	3
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.527	4
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	3
UniProt:Q9HBE1 PATZ1			0.527	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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