Reactome | RPL29 [cytosol]

RPL29 [cytosol]

Stable Identifier

R-HSA-72446

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L29, Cell surface heparin binding protein HIP

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL29 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P47914 RPL29

Gene Names

RPL29

Chain

initiator methionine:, chain:2-159

Reference Genes

BioGPS Gene:6159 RPL29

COSMIC (genes):RPL29 RPL29

CTD Gene:6159 RPL29

dbSNP Gene:6159 RPL29

ENSEMBL:ENSG00000162244 RPL29

ENSEMBL_homo_sapiens_GENE:ENSG00000162244.12 RPL29

HGNC:10331 RPL29

KEGG Gene (Homo sapiens):6159 RPL29

Monarch:6159 RPL29

NCBI Gene:6159 RPL29

OMIM:601832 RPL29

UCSC:P47914 RPL29

Reference Transcript

RefSeq:NM_000992.2 RPL29

Other Identifiers

11744548_x_at

200823_3p_x_at

200823_PM_x_at

200823_x_at

213969_3p_x_at

213969_PM_x_at

213969_x_at

2325070

2669174

2669175

2675860

2675861

2675862

2675866

2675868

2675869

2675870

2675871

2709548

2923187

2923188

33674_at

3466486

3466488

3466489

3466490

3722553

3859279

6159

8086148

8087830

A_23_P257609

GE79121

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0007566

GO:0008201

GO:0016020

GO:0022414

GO:0022625

GO:0022626

GO:0043226

GO:0045296

GO:0048856

GO:1990904

HMNXSV003054806

Hs.183698.2.S1_3p_a_at

ILMN_1737517

ILMN_1771051

PH_hs_0019917

TC03001444.hg

Z49148_s_at

g4506628_3p_a_at

Participates

as a component of

Inferred To

rpl29 [cytosol] (Danio rerio)

rpl29 [cytosol] (Dictyostelium discoideum)

rpl29 [cytosol] (Schizosaccharomyces pombe)

rpl29 [cytosol] (Xenopus tropicalis)

LOC120093247 [cytosol] (Rattus norvegicus)

Homologues of RPL29 [cytosol] (Rattus norvegicus)

RPL29 [cytosol] (Bos taurus)

RPL29 [cytosol] (Canis familiaris)

RPL29 [cytosol] (Gallus gallus)

RPL29 [cytosol] (Plasmodium falciparum)

RPL29 [cytosol] (Saccharomyces cerevisiae)

RPL29 [cytosol] (Sus scrofa)

rpl-29 [cytosol] (Caenorhabditis elegans)

RpL29 [cytosol] (Drosophila melanogaster)

Rpl29 [cytosol] (Mus musculus)

Rpl29 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_000983.1

OpenTargets

ENSG00000162244

GeneCards

P47914

HPA

ENSG00000162244-RPL29

Ensembl

ENSP00000418346, ENSP00000294189, ENSP00000418153, ENST00000492277, ENST00000495383, ENST00000479017, ENSG00000162244, ENSP00000420673, ENST00000294189, ENSP00000418868, ENSP00000417048, ENST00000475248, ENST00000466397

PRO

P47914

Pharos - Targets

P47914

HMDB Protein

HMDBP10728

PDB

8IPD, 8OJ5, 6LSS, 6OLG, 6Z6M, 8OJ8, 7QVP, 6Y57, 6Z6L, 7OW7, 8OJ0, 6ZMO, 6OLF, 8IFE, 5AJ0, 8IFD, 8Y0W, 7BHP, 8FL9, 6ZMI, 8FL7, 8IPY, 6OLE, 5T2C, 6LQM, 8FLF, 6OM0, 6IP6, 8FLE, 6IP5, 8GLP, 8A3D, 6XA1, 4V6X, 6W6L, 6Z6N, 6Y6X, 8FLB, 8FLA, 8G61, 8JDL, 6LSR, 8G5Y, 8INF, 8INE, 8JDK, 8IDY, 8IE3, 8G60, 8JDJ, 4UG0, 6LU8, 7F5S, 8IDT, 6OM7, 6Y2L, 6IP8, 8IPX, 6Y0G, 8Y0X, 8QFD, 6OLZ, 6QZP, 7XNY, 8FL6, 6ZME, 7XNX, 8G6J, 8FLD, 8FLC, 8INK, 6ZM7, 8OHD, 6OLI, 8JDM

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [nucleoplasm] (R-HSA-266221) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422)	0.553	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2

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