Reactome | RPL4 [cytosol]

RPL4 [cytosol]

Stable Identifier

R-HSA-72474

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L4, L1

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P36578 RPL4

Gene Names

RPL4, RPL1

Chain

initiator methionine:, chain:2-427

Reference Genes

BioGPS Gene:6124 RPL4

COSMIC (genes):RPL4 RPL4

CTD Gene:6124 RPL4

dbSNP Gene:6124 RPL4

ENSEMBL:ENSG00000174444 RPL4

HGNC:10353 RPL4

KEGG:hsa:6124 RPL4

Monarch:6124 RPL4

NCBI Gene:6124 RPL4

OMIM:180479 RPL4

UCSC:P36578 RPL4

Reference Transcript

RefSeq:NM_000968.3 RPL4

Other Identifiers

11756140_s_at

11757179_x_at

11762875_a_at

16651205

16651207

16651209

16651211

16651213

16651215

16651217

16651219

16651221

16651223

16651225

16651227

16651229

16651231

16651233

16651235

16651237

16651243

16651245

16651247

16651249

16810954

16810970

16810972

16810974

16810976

18671445

18671446

18671447

18671448

18671449

18671450

18671451

18671452

18671453

18671454

18671455

18671456

18671457

18671458

18671459

18671460

18671461

200089_PM_s_at

200089_s_at

201154_PM_x_at

201154_x_at

211710_PM_x_at

211710_x_at

2708792

2708793

2708795

2708796

2708797

2708800

2708801

2708802

2708804

3198241

33485_at

3630171

3630172

3630173

3630177

3630179

3630181

3630182

3630183

3630184

3630185

3630187

3630188

3630189

3630190

3630191

3630192

3630193

3630194

3630195

3630196

3630197

3630198

3630199

3630200

3630201

3630202

3630203

3630204

3630205

3630206

3630207

3630208

3630209

3630210

3630211

3630212

3630213

3630215

3630217

3630219

3630223

3630225

52028_at

6124

7892536

7892640

7892676

7893216

7893305

7893323

7893386

7893559

7893766

7893823

7893904

7894051

7895429

7896084

7896168

7896397

7896554

7989932

80081_at

8180297

A_21_P0000244

A_21_P0000245

A_21_P0000246

A_21_P0000247

A_23_P69431

D23660_at

GE61383

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0005925

GO:0006396

GO:0006412

GO:0016020

GO:0022625

GO:0022626

GO:0043226

GO:0070062

GO:1990904

HMNXSV003001638

HMNXSV003009077

HMNXSV003019909

HMNXSV003032672

HMNXSV003049676

Hs.286.4.A1_3p_s_at

ILMN_1669210

ILMN_1680179

ILMN_1721749

ILMN_1752285

PH_hs_0029384

PH_hs_0032060

RNA33555|snoRNA_scaRNA_151_101

RNA33756|snoRNA_scaRNA_352_70

RNA33760|snoRNA_scaRNA_356_70

RNA33774|snoRNA_scaRNA_370_67

TC15001579.hg

TC15001580.hg

TC15001581.hg

TC15001582.hg

TC15002586.hg

TC15002587.hg

Participates

as a component of

Inferred To

Rpl4 [cytosol] (Mus musculus)

Rpl4 [cytosol] (Rattus norvegicus)

rpl-4 [cytosol] (Caenorhabditis elegans)

RPL4B [cytosol] (Saccharomyces cerevisiae)

RPL4A [cytosol] (Saccharomyces cerevisiae)

RpL4 [cytosol] (Drosophila melanogaster)

RPL4 [cytosol] (Bos taurus)

RPL4 [cytosol] (Canis familiaris)

RPL4 [cytosol] (Gallus gallus)

RPL4 [cytosol] (Plasmodium falciparum)

RPL4 [cytosol] (Sus scrofa)

rpl402 [cytosol] (Schizosaccharomyces pombe)

Homologues of RPL4 [cytosol] (Saccharomyces cerevisiae)

rpl4 [cytosol] (Danio rerio)

rpl4 [cytosol] (Dictyostelium discoideum)

rpl4 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_000959.2

OpenTargets

ENSG00000174444

ENSEMBL

ENST00000307961, ENSP00000311430

HPA

ENSG00000174444-RPL4

PRO

P36578

Pharos - Targets

P36578

GlyGen

P36578

PDB

5LKS, 8G6J, 8FL3, 8G60, 7BHP, 6OLF, 7OW7, 8FLA, 8Y0X, 8A3D, 8INE, 6OLZ, 8OJ5, 7XNX, 8JDL, 8JDJ, 6OLE, 6LSS, 6OM0, 6ZMO, 8FLE, 8IFD, 6LSR, 6Z6L, 6Y6X, 8QFD, 6OLI, 8OJ8, 8FL6, 8FKX, 8FKW, 6LQM, 8FKP, 6ZME, 8FL0, 6IP8, 8IDT, 6Y57, 8FL7, 8GLP, 8FKQ, 5AJ0, 8IPY, 8FKT, 6QZP, 6ZM7, 8FKS, 8FKZ, 6OM7, 8IE3, 8FKR, 8INF, 8JDM, 8JDK, 4UG0, 6OLG, 8QOI, 8FLF, 8G61, 8IFE, 8G5Y, 6ZMI, 8Y0W, 7XNY, 8FLD, 8INK, 6Z6N, 8FLB, 8FLC, 4V6X, 6Z6M, 7QVP, 8G5Z, 6Y0G, 5A8L, 8FL9, 8FKU, 6IP6, 6IP5, 8IDY, 8IPD, 6Y2L, 6XA1, 8FKV, 8IR1, 8IR3, 6LU8, 8FL4, 6W6L, 8OHD, 8IPX, 8FL2, 8FKY, 5T2C, 8OJ0, 7F5S

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.706	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	14
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	4
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	3
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.527	2
UniProt:P62263 RPS14	2	RPS14 [cytosol] (R-HSA-72333) RPS14 [nucleoplasm] (R-HSA-6790669)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	2
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	3
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
UniProt:P40429 RPL13A	2	RPL13A [cytosol] (R-HSA-72412) p-RPL13A [cytosol] (R-HSA-156829)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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