Reactome | RPL8 [cytosol]

RPL8 [cytosol]

Stable Identifier

R-HSA-72490

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L8, P25120

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62917 RPL8

Gene Names

RPL8

Chain

initiator methionine:, chain:2-257

Reference Genes

BioGPS Gene:6132 RPL8

COSMIC (genes):RPL8 RPL8

CTD Gene:6132 RPL8

dbSNP Gene:6132 RPL8

ENSEMBL:ENSG00000161016 RPL8

ENSEMBL_homo_sapiens_GENE:ENSG00000161016.18 RPL8

HGNC:10368 RPL8

KEGG Gene (Homo sapiens):6132 RPL8

Monarch:6132 RPL8

NCBI Gene:6132 RPL8

OMIM:604177 RPL8

UCSC:P62917 RPL8

Reference Transcript

Other Identifiers

11744120_a_at

11753565_x_at

11756258_x_at

17082873

200936_PM_at

200936_at

31505_at

3159041

3159042

3159044

3159049

3159050

3159051

3159053

3159054

3159055

3159057

3159058

3159059

3159060

3159062

3928439

6132

8153903

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0014069

GO:0015934

GO:0016020

GO:0019843

GO:0022625

GO:0022626

GO:0043226

GO:0045202

GO:0098794

GO:1990904

HMNXSV003000800

HMNXSV003004133

ILMN_1764721

ILMN_1811433

PH_hs_0010606

TC08001762.hg

Z28407_at

g4506662_3p_at

Participates

as a component of

Other forms of this molecule

3OHH216-RPL8 [nucleoplasm]

RPL8 [nucleoplasm]

Inferred To

Rpl8 [cytosol] (Mus musculus)

Rpl8 [cytosol] (Rattus norvegicus)

RPL2B [cytosol] (Saccharomyces cerevisiae)

rpl802 [cytosol] (Schizosaccharomyces pombe)

rpl8 [cytosol] (Danio rerio)

rpl8 [cytosol] (Dictyostelium discoideum)

rpl8 [cytosol] (Xenopus tropicalis)

rpl-2 [cytosol] (Caenorhabditis elegans)

RPL2A [cytosol] (Saccharomyces cerevisiae)

rpl801 [cytosol] (Schizosaccharomyces pombe)

Homologues of RPL8 [cytosol] (Saccharomyces cerevisiae)

Homologues of RPL8 [cytosol] (Schizosaccharomyces pombe)

RPL8 [cytosol] (Bos taurus)

RPL8 [cytosol] (Canis familiaris)

RPL8 [cytosol] (Gallus gallus)

RPL8 [cytosol] (Plasmodium falciparum)

RPL8 [cytosol] (Sus scrofa)

RpL8 [cytosol] (Drosophila melanogaster)

rpl803 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_150644.1, NP_000964.1, NP_001304711.1, NP_001304700.1

OpenTargets

ENSG00000161016

HPA

ENSG00000161016-RPL8

GeneCards

P62917

Ensembl

ENSG00000161016, ENST00000262584, ENST00000528957, ENST00000394920, ENSP00000262584, ENSP00000378378, ENSP00000433464

PRO

P62917

Pharos - Targets

P62917

PDB

5LKS, 4V6X, 6Z6N, 6W6L, 6OLI, 8OHD, 8IR3, 6Z6M, 6LU8, 6LQM, 4CCO, 8INK, 8IR1, 8FLF, 5T2C, 8INF, 6IP8, 6OLG, 6Z6L, 8FLE, 6OLF, 8FLD, 6OLZ, 8IE3, 4CCM, 6OM0, 5AJ0, 8JDJ, 8FL6, 8FL4, 6OLE, 6OM7, 8IDY, 7XNY, 7XNX, 8A3D, 6XA1, 8IDT, 7UN3, 6Y0G, 8JDM, 6Y6X, 6LSR, 6LSS, 8FL9, 8OJ5, 6ZM7, 8OJ0, 8JDK, 4Y3O, 8IPD, 6Y57, 8JDL, 6ZMO, 7OW7, 8FL7, 6QZP, 8IFE, 6Y2L, 8IPY, 6IP6, 6IP5, 6ZMI, 8INE, 8FLC, 8Y0X, 4UG0, 8QFD, 4CCN, 8Y0W, 8FKZ, 8FLB, 8FLA, 8IFD, 8IPX, 8OJ8, 7BHP, 8FL3, 6ZME, 8FL2, 7F5S

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	20
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.564	3
UniProt:Q9UQ80 PA2G4	2	PA2G4 [extracellular region] (R-HSA-6806200) PA2G4 [azurophil granule lumen] (R-HSA-6799205)	0.528	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	2
UniProt:P42696 RBM34			0.527	3
UniProt:Q02543 RPL18A	1	RPL18A [cytosol] (R-HSA-72422)	0.527	2
UniProt:P51608 MECP2			0.527	3
UniProt:Q9GZR2 REXO4			0.527	2
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
UniProt:Q14684 RRP1B			0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q15397 PUM3			0.527	3
UniProt:Q6PK04 CC137			0.527	2
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:Q13823 NOG2			0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:Q96ME7 ZN512			0.527	3
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:Q8NDF8 PAPD5			0.527	3
UniProt:O43167 ZBT24			0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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