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EIF2S1 [cytosol]
Stable Identifier
R-HSA-72510
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF2-alpha, eIF-2-alpha, translation initiation factor 2 alpha subunit, translation initiation factor 2, subunit 1, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 alpha subunit, EIF- 2alpha, EIF-2A
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to mitochondrial stress (Homo sapiens)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates eIF2-alpha (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
De novo formation of eIF2:GTP (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Met-tRNAi binds to eIF2:GTP to form the ternary complex (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
eIF2:GDP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
eIF2:GDP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
eIF2 activation (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABCF1 binds EIF2 (Homo sapiens)
ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05198 EIF2S1
Gene Names
EIF2S1, EIF2A
Chain
chain:1-315
Reference Genes
BioGPS Gene:1965 EIF2S1
COSMIC (genes):EIF2A EIF2S1
COSMIC (genes):EIF2S1 EIF2S1
CTD Gene:1965 EIF2S1
dbSNP Gene:1965 EIF2S1
ENSEMBL:ENSG00000134001 EIF2S1
HGNC:3265 EIF2S1
KEGG:hsa:1965 EIF2S1
Monarch:1965 EIF2S1
NCBI Gene:1965 EIF2S1
OMIM:603907 EIF2S1
UCSC:P05198 EIF2S1
Reference Transcript
RefSeq:NM_004094.4 EIF2S1
Other Identifiers
1154_at
11716219_a_at
11716220_x_at
11716221_at
11749910_a_at
11752101_s_at
16785631
1965
201142_PM_at
201142_at
201143_PM_s_at
201143_s_at
201144_PM_s_at
201144_s_at
3541138
3541139
3541140
3541141
3541142
3541143
3541145
3541146
3541150
3541151
3541152
3541155
3541157
3541159
3541160
3541161
3541162
3541163
3541164
3541165
3541166
3541167
3541172
39784_at
7975224
A_14_P121759
A_14_P130960
A_24_P138556
A_24_P356015
A_33_P3402171
GE57464
GE891206
GO:0000423
GO:0003676
GO:0003723
GO:0003743
GO:0005515
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005850
GO:0006412
GO:0006413
GO:0006417
GO:0006914
GO:0007005
GO:0010494
GO:0016020
GO:0032057
GO:0033290
GO:0034063
GO:0034198
GO:0034599
GO:0034605
GO:0034644
GO:0034976
GO:0036490
GO:0036499
GO:0043022
GO:0043226
GO:0043558
GO:0044207
GO:0045182
GO:0045202
GO:0070062
GO:0097451
GO:0140468
GO:1904373
GO:1990737
GO:2000676
HMNXSV003029192
Hs.151777.0.A3_3p_at
ILMN_1739821
J02645_at
PH_hs_0009146
TC14000406.hg
U26032_at
g12803384_3p_a_at
g4758255_3p_a_at
Participates
as a component of
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S52-EIF2S1 [cytosol]
Inferred To
Eif2s1 [cytosol]
(Mus musculus)
Eif2s1 [cytosol]
(Rattus norvegicus)
tif211 [cytosol]
(Schizosaccharomyces pombe)
eif2s1b [cytosol]
(Danio rerio)
eif2s1 [cytosol]
(Dictyostelium discoideum)
eif2s1 [cytosol]
(Xenopus tropicalis)
eif-2alpha [cytosol]
(Caenorhabditis elegans)
SUI2 [cytosol]
(Saccharomyces cerevisiae)
EIF2S1 [cytosol]
(Bos taurus)
EIF2S1 [cytosol]
(Canis familiaris)
EIF2S1 [cytosol]
(Gallus gallus)
EIF2S1 [cytosol]
(Sus scrofa)
eIF2alpha [cytosol]
(Drosophila melanogaster)
eIF2alpha [cytosol]
(Plasmodium falciparum)
Cross References
RefSeq
NP_004085.1
OpenTargets
ENSG00000134001
ENSEMBL
ENST00000466499
,
ENST00000256383
,
ENSP00000256383
,
ENSP00000425299
HPA
ENSG00000134001-EIF2S1
PRO
P05198
Pharos - Targets
P05198
GlyGen
P05198
HMDB Protein
HMDBP02276
PDB
6O85
,
6K71
,
7D44
,
8OZ0
,
6ZMW
,
6YBV
,
7F66
,
7SYR
,
7F67
,
6ZP4
,
7QP6
,
6K72
,
1Q8K
,
1KL9
,
7SYS
,
8PPL
,
7D45
,
7D43
,
6O81
,
8QZZ
,
7NZM
,
7A09
,
6O9Z
,
7QP7
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19525 EIF2AK2
5
EIF2AK2 [cytosol]
(R-HSA-168699)
p-EIF2AK2 [nucleoplasm]
(R-HSA-9836332)
p-EIF2AK2 [cytosol]
(R-HSA-9833834)
ISG15-EIF2AK2 [cytosol]
(R-HSA-9833968)
SUMO-EIF2AK2 [cytosol]
(R-HSA-9834829)
0.783
5
UniProt:Q9Z2B5 Eif2ak3
2
Eif2ak3 [endoplasmic reticulum membrane]
(R-MMU-9842185)
EIF2AK3 [endoplasmic reticulum membrane]
(R-MMU-381046)
0.655
4
UniProt:O75807 PPP1R15A
1
PPP1R15A [cytosol]
(R-HSA-178231)
0.623
3
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.556
3
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
5
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.509
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
7
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