Reactome | EIF2B2 [cytosol]

EIF2B2 [cytosol]

Stable Identifier

R-HSA-72519

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF2B-beta, translation initiation factor 2B beta subunit, eIF-2B GDP-GTP exchange factor, beta subunit, Translation initiation factor eIF-2B beta subunit, eIF-2B GDP-GTP exchange factor, S20I15, S20III15

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49770 EIF2B2

Gene Names

EIF2B2, EIF2BB

Chain

chain:1-351

Reference Genes

BioGPS Gene:8892 EIF2B2

COSMIC (genes):EIF2B2 EIF2B2

CTD Gene:8892 EIF2B2

dbSNP Gene:8892 EIF2B2

ENSEMBL:ENSG00000119718 EIF2B2

HGNC:3258 EIF2B2

KEGG:hsa:8892 EIF2B2

Monarch:8892 EIF2B2

NCBI Gene:8892 EIF2B2

OMIM:606454 EIF2B2

UCSC:P49770 EIF2B2

Reference Transcript

RefSeq:NM_014239.3 EIF2B2

Other Identifiers

11717673_a_at

11717674_s_at

16786548

202461_PM_at

202461_at

3544405

3544406

3544407

3544408

3544409

3544410

3544413

3544414

3544415

3544416

3544417

3544418

3544419

3544421

3544422

3544423

3544424

3544425

3544426

3544427

3544429

3544431

40515_at

50009_at

54571_at

7975760

8892

A_14_P120799

A_23_P25929

GE500449

GE54270

GO:0001541

GO:0002183

GO:0002376

GO:0003743

GO:0005085

GO:0005515

GO:0005524

GO:0005525

GO:0005737

GO:0005829

GO:0005851

GO:0006412

GO:0006413

GO:0006446

GO:0007417

GO:0009408

GO:0009749

GO:0014003

GO:0042552

GO:0043434

GO:0044237

GO:0045182

GO:0048856

GO:0050852

GO:0098772

HMNXSV003043237

ILMN_1713380

L40395_at

PH_hs_0020574

PH_hs_0026518

TC14000466.hg

g7657057_3p_at

g7657057_3p_s_at

g7657057_3p_x_at

Participates

as a component of

eIF2B subunits complex [cytosol] (Homo sapiens)

Inferred To

eif2b2 [cytosol] (Danio rerio)

eif2b2 [cytosol] (Dictyostelium discoideum)

eif2b2 [cytosol] (Xenopus tropicalis)

Eif2b2 [cytosol] (Mus musculus)

Eif2b2 [cytosol] (Rattus norvegicus)

GCD7 [cytosol] (Saccharomyces cerevisiae)

eIF2Bbeta [cytosol] (Drosophila melanogaster)

EIF2B2 [cytosol] (Bos taurus)

EIF2B2 [cytosol] (Canis familiaris)

EIF2B2 [cytosol] (Gallus gallus)

EIF2B2 [cytosol] (Plasmodium falciparum)

EIF2B2 [cytosol] (Sus scrofa)

eif-2bbeta [cytosol] (Caenorhabditis elegans)

tif222 [cytosol] (Schizosaccharomyces pombe)

Cross References

OpenTargets

ENSG00000119718

ENSEMBL

ENSG00000119718, ENSP00000266126, ENST00000266126

HPA

ENSG00000119718-EIF2B2

GeneCards

EIF2B2

PRO

P49770

Pharos - Targets

P49770

Orphanet

EIF2B2

HMDB Protein

HMDBP08375

PDB

7VLK, 7RLO, 6O85, 7KMF, 7F64, 7TRJ, 7D44, 6K71, 6CAJ, 7F66, 8TQZ, 7D46, 7D43, 6O9Z, 8TQO, 7L7G, 6O81, 7L70, 7D45, 6EZO, 7F67, 6K72

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:P32249 GPR183	1	GPR183 [plasma membrane] (R-HSA-8851676)	0.527	4
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:O14975 SLC27A2	5	SLC27A2 [cytosol] (R-HSA-9033090) SLC27A2 [endoplasmic reticulum membrane] (R-HSA-193386) SLC27A2 [plasma membrane] (R-HSA-6806316) SLC27A2 [specific granule membrane] (R-HSA-6799565) SLC27A2 [peroxisomal membrane] (R-HSA-389579)	0.527	2
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:Q8NCR0 B3GALNT2	1	B3GALNT2 [endoplasmic reticulum membrane] (R-HSA-8878916)	0.527	2
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.527	2
UniProt:P21579 SYT1	7	SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113)	0.527	3
UniProt:P62987 UBA52	20	UBA52(1-76) [endocytic vesicle membrane] (R-HSA-939236) Ub-33-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783187) Ub-63-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783039) Ub-6-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783072) Ub-11-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783059) Ub-48-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783049) Ub-29-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783030) Ub-63-UBA52(1-76) [cytosol] (R-HSA-939169) UBA52(1-76) [lysosomal lumen] (R-HSA-9660000) UBA52(1-76) [cytosol] (R-HSA-939203) p-S65-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-9834996) Ub-48-UBA52(1-76) [cytosol] (R-HSA-939250) UBA52(1-76) [mitochondrial outer membrane] (R-HSA-9834955) UBA52(1-76) [late endosome lumen] (R-HSA-9660003) Ub-6-UBA52(1-76) [nucleoplasm] (R-HSA-6782616) Ub-63-UBA52(1-76) [nucleoplasm] (R-HSA-6782530) Ub-48-UBA52(1-76) [nucleoplasm] (R-HSA-5683034) UBA52(1-76) [nucleoplasm] (R-HSA-939844) Ub-63-UBA52(1-76) [plasma membrane] (R-HSA-939851) Ub-63-UBA52(1-76) [endosome membrane] (R-HSA-939185)	0.527	2

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