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EIF3B [cytosol]
Stable Identifier
R-HSA-72542
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3-eta, eIF-3 eta, eIF3b, eIF3 p116, eIF3 p110, eukaryotic translation initiation factor 3 subunit 9, Eukaryotic translation initiation factor 3 subunit 9
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55884 EIF3B
Gene Names
EIF3B, EIF3S9
Chain
chain:1-814
Reference Genes
BioGPS Gene:8662 EIF3B
COSMIC (genes):EIF3B EIF3B
CTD Gene:8662 EIF3B
dbSNP Gene:8662 EIF3B
ENSEMBL:ENSG00000106263 EIF3B
ENSEMBL_homo_sapiens_GENE:ENSG00000106263.19 EIF3B
HGNC:3280 EIF3B
KEGG Gene (Homo sapiens):8662 EIF3B
Monarch:8662 EIF3B
NCBI Gene:8662 EIF3B
OMIM:603917 EIF3B
UCSC:P55884 EIF3B
Reference Transcript
RefSeq:XM_011515599.1 EIF3B
RefSeq:NM_001037283.1 EIF3B
RefSeq:XM_011515600.1 EIF3B
RefSeq:NM_003751.3 EIF3B
RefSeq:XM_017012752.1 EIF3B
Other Identifiers
11720073_s_at
11720074_x_at
11725630_a_at
11745971_s_at
11745972_x_at
11750785_x_at
11757048_x_at
17042946
203462_PM_x_at
203462_x_at
208688_PM_x_at
208688_x_at
211501_3p_s_at
211501_PM_s_at
211501_s_at
2987446
2987447
2987448
2987449
2987450
2987451
2987452
2987453
2987454
2987455
2987457
2987458
2987460
2987463
2987466
2987469
2987472
2987474
2987476
2987478
2987483
2987485
2987487
2987489
2987490
2987491
2987492
2987493
35323_at
8131111
8662
A_14_P109217
A_23_P157072
A_33_P3239222
GE59427
GO:0001732
GO:0002181
GO:0002183
GO:0003676
GO:0003723
GO:0003743
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005852
GO:0006412
GO:0006413
GO:0006446
GO:0010494
GO:0016282
GO:0031369
GO:0033290
GO:0043226
GO:0045182
GO:0045202
GO:0060090
GO:0065003
GO:0070062
GO:0071541
GO:0075522
GO:0075525
HMNXSV003005807
ILMN_1715636
ILMN_2278729
ILMN_2379469
PH_hs_0024167
TC07000030.hg
TC07002107.hg
TC07002108.hg
U78525_at
g12654668_3p_a_at
g12654668_3p_x_at
g2558667_3p_x_at
g4503526_3p_a_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
Ghost homologue of EIF3B [cytosol]
(Danio rerio)
Ghost homologue of EIF3B [cytosol]
(Xenopus tropicalis)
eIF3b [cytosol]
(Drosophila melanogaster)
EIF3B [cytosol]
(Bos taurus)
EIF3B [cytosol]
(Canis familiaris)
EIF3B [cytosol]
(Gallus gallus)
EIF3B [cytosol]
(Plasmodium falciparum)
EIF3B [cytosol]
(Schizosaccharomyces pombe)
EIF3B [cytosol]
(Sus scrofa)
Eif3b [cytosol]
(Mus musculus)
Eif3b [cytosol]
(Rattus norvegicus)
eif3B [cytosol]
(Dictyostelium discoideum)
PRT1 [cytosol]
(Saccharomyces cerevisiae)
eif-3.B [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_003742.2
,
XP_016868241.1
,
NP_001032360.1
,
XP_011513901.1
,
XP_011513902.1
OpenTargets
ENSG00000106263
HPA
ENSG00000106263-EIF3B
GeneCards
P55884
Ensembl
ENSP00000354125
,
ENSP00000380206
,
ENSG00000106263
,
ENST00000360876
,
ENST00000397011
PRO
P55884
Pharos - Targets
P55884
PDB
7QP6
,
6YBT
,
6ZVJ
,
6ZON
,
7QP7
,
6ZP4
,
8OZ0
,
5K1H
,
2KRB
,
2NLW
,
6ZMW
,
7A09
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.643
8
UniProt:Q04637 EIF4G1
2
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
EIF4G1 [cytosol]
(R-HSA-72584)
0.564
2
UniProt:P23443 RPS6KB1
2
RPS6KB1 [cytosol]
(R-HSA-165716)
p-T412-RPS6KB1 [cytosol]
(R-HSA-165714)
0.564
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.462
8
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