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EIF3D [cytosol]
Stable Identifier
R-HSA-72548
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3-zeta, eIF-3 zeta, eIF3d, eIF3 p66, eukaryotic translation initiation factor 3 subunit 7, Eukaryotic translation initiation factor 3 subunit 7
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15371 EIF3D
Gene Names
EIF3D, EIF3S7
Chain
chain:1-548
Reference Genes
BioGPS Gene:8664 EIF3D
COSMIC (genes):EIF3D EIF3D
CTD Gene:8664 EIF3D
dbSNP Gene:8664 EIF3D
ENSEMBL:ENSG00000100353 EIF3D
ENSEMBL_homo_sapiens_GENE:ENSG00000100353.18 EIF3D
HGNC:3278 EIF3D
KEGG Gene (Homo sapiens):8664 EIF3D
Monarch:8664 EIF3D
NCBI Gene:8664 EIF3D
OMIM:603915 EIF3D
UCSC:O15371 EIF3D
Reference Transcript
RefSeq:NM_003753.3 EIF3D
Other Identifiers
11719180_a_at
16934583
18671598
18671600
18671601
18671604
18671605
18671607
18671608
18671610
18671611
18671612
18671613
18671614
18671615
18671616
18671619
18671620
200005_PM_at
200005_at
35298_at
3959632
3959634
3959635
3959636
3959638
3959643
3959644
3959645
3959649
3959650
3959651
3959653
3959654
3959656
3959657
3959658
3959660
3959661
3959662
3959663
7893023
7893249
7893973
7894019
7894289
7894306
7894496
7894561
7894968
7895238
7895939
7895947
7895996
7896025
7896139
7896512
8075798
8664
A_23_P91699
A_23_P91702
GE79549
GO:0001732
GO:0002181
GO:0002183
GO:0002191
GO:0003723
GO:0003743
GO:0005515
GO:0005737
GO:0005829
GO:0005852
GO:0006412
GO:0006413
GO:0016020
GO:0016282
GO:0033290
GO:0045182
GO:0045202
GO:0045727
GO:0065003
GO:0071541
GO:0075522
GO:0075525
GO:0098808
GO:1902416
HMNXSV003024188
ILMN_1739847
PH_hs_0003644
TC22000711.hg
g4503522_3p_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
moe1 [cytosol]
(Schizosaccharomyces pombe)
eIF3d1 [cytosol]
(Drosophila melanogaster)
Ghost homologue of EIF3D [cytosol]
(Saccharomyces cerevisiae)
eif-3.D [cytosol]
(Caenorhabditis elegans)
EIF3D [cytosol]
(Bos taurus)
EIF3D [cytosol]
(Canis familiaris)
EIF3D [cytosol]
(Gallus gallus)
EIF3D [cytosol]
(Plasmodium falciparum)
EIF3D [cytosol]
(Sus scrofa)
Eif3d [cytosol]
(Mus musculus)
Eif3d [cytosol]
(Rattus norvegicus)
eif3d [cytosol]
(Danio rerio)
eif3d [cytosol]
(Dictyostelium discoideum)
eif3d [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003744.1
OpenTargets
ENSG00000100353
HPA
ENSG00000100353-EIF3D
GeneCards
O15371
Ensembl
ENST00000216190
,
ENST00000405442
,
ENSG00000100353
,
ENSP00000385812
,
ENSP00000216190
PRO
O15371
Pharos - Targets
O15371
PDB
6ZON
,
6ZMW
,
7A09
,
6ZVJ
,
7QP7
,
6ZP4
,
7QP6
,
6YBD
,
6YBS
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.718
6
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.547
5
UniProt:Q8WV24 PHLDA1
2
p-S95-PHLDA1 [cytosol]
(R-HSA-8853443)
PHLDA1 [cytosol]
(R-HSA-8853431)
0.508
2
UniProt:P04049 RAF1
20
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
0.508
4
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