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EIF3D [cytosol]
Stable Identifier
R-HSA-72548
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3-zeta, eIF-3 zeta, eIF3d, eIF3 p66, eukaryotic translation initiation factor 3 subunit 7, Eukaryotic translation initiation factor 3 subunit 7
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3D [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15371 EIF3D
Gene Names
EIF3D, EIF3S7
Chain
chain:1-548
Reference Genes
BioGPS Gene:8664 EIF3D
COSMIC (genes):EIF3D EIF3D
CTD Gene:8664 EIF3D
dbSNP Gene:8664 EIF3D
ENSEMBL:ENSG00000100353 EIF3D
HGNC:3278 EIF3D
KEGG:hsa:8664 EIF3D
Monarch:8664 EIF3D
NCBI Gene:8664 EIF3D
OMIM:603915 EIF3D
UCSC:O15371 EIF3D
Reference Transcript
RefSeq:NM_003753.3 EIF3D
Other Identifiers
11719180_a_at
16653073
16653075
16653077
16653079
16653093
16653095
16653097
16653099
16653103
16653105
16653115
16653117
16653119
16653121
16653123
16653127
16653129
16653131
16653133
16653135
16653137
16653139
16653141
16653143
16653145
16653147
16653149
16653151
16653153
16653155
16934583
18671598
18671599
18671600
18671601
18671602
18671603
18671604
18671605
18671606
18671607
18671608
18671609
18671610
18671611
18671612
18671613
18671614
18671615
18671616
18671617
18671618
18671619
18671620
200005_PM_at
200005_at
35298_at
3959632
3959633
3959634
3959635
3959636
3959638
3959639
3959642
3959643
3959644
3959645
3959646
3959647
3959648
3959649
3959650
3959651
3959653
3959654
3959655
3959656
3959657
3959658
3959659
3959660
3959661
3959662
3959663
3959664
3959666
3959676
3959678
3959680
3959682
3959684
3959686
3959688
3959690
3959692
3959694
3959696
3959698
3959704
3959706
3959710
3959716
3959718
3959720
3959722
3959724
3959726
3959728
3959730
3959732
3959734
3959736
3959738
3959740
3959744
7892789
7893023
7893049
7893249
7893267
7893448
7893579
7893848
7893899
7893973
7894015
7894019
7894052
7894080
7894184
7894289
7894306
7894401
7894443
7894496
7894561
7894833
7894842
7894861
7894876
7894968
7895004
7895021
7895238
7895268
7895280
7895663
7895682
7895804
7895807
7895845
7895864
7895874
7895894
7895939
7895947
7895996
7896025
7896139
7896183
7896314
7896512
8075798
8664
A_23_P91699
A_23_P91702
A_33_P3420841
GE79549
GO:0001732
GO:0002191
GO:0003723
GO:0003743
GO:0005515
GO:0005737
GO:0005829
GO:0005852
GO:0006412
GO:0006413
GO:0016020
GO:0016282
GO:0033290
GO:0045182
GO:0045202
GO:0045727
GO:0065003
GO:0071541
GO:0075522
GO:0075525
GO:0098808
GO:1902416
HMNXSV003024188
HMNXSV003027402
ILMN_1739847
PH_hs_0003644
TC22000711.hg
g4503522_3p_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
moe1 [cytosol]
(Schizosaccharomyces pombe)
eIF3d1 [cytosol]
(Drosophila melanogaster)
Ghost homologue of EIF3D [cytosol]
(Saccharomyces cerevisiae)
eif-3.D [cytosol]
(Caenorhabditis elegans)
EIF3D [cytosol]
(Bos taurus)
EIF3D [cytosol]
(Canis familiaris)
EIF3D [cytosol]
(Gallus gallus)
EIF3D [cytosol]
(Plasmodium falciparum)
EIF3D [cytosol]
(Sus scrofa)
Eif3d [cytosol]
(Mus musculus)
Eif3d [cytosol]
(Rattus norvegicus)
eif3d [cytosol]
(Danio rerio)
eif3d [cytosol]
(Dictyostelium discoideum)
eif3d [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003744.1
ENSEMBL
ENST00000216190
,
ENST00000405442
,
ENSP00000385812
,
ENSP00000216190
OpenTargets
ENSG00000100353
HPA
ENSG00000100353-EIF3D
PRO
O15371
Pharos - Targets
O15371
GlyGen
O15371
PDB
6YBD
,
6YBS
,
8XXN
,
8PPL
,
6ZMW
,
8OZ0
,
6ZP4
,
7QP6
,
6ZON
,
6ZVJ
,
7QP7
,
7A09
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.718
6
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.547
5
UniProt:O95714 HERC2
5
HERC2 [nucleoplasm]
(R-HSA-4551680)
p-T4827-HERC2 [nucleoplasm]
(R-HSA-5682601)
p-T4827,SUMO1-HERC2 [nucleoplasm]
(R-HSA-5682615)
HERC2 [cytosol]
(R-HSA-975975)
monoSUMO1-HERC2 [nucleoplasm]
(R-HSA-4551758)
0.527
2
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.508
4
UniProt:Q8WV24 PHLDA1
3
PHLDA1 [nucleoplasm]
(R-HSA-9843223)
p-S95-PHLDA1 [cytosol]
(R-HSA-8853443)
PHLDA1 [cytosol]
(R-HSA-8853431)
0.508
2
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