Reactome | EIF3E [cytosol]

EIF3E [cytosol]

Stable Identifier

R-HSA-72552

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF3e, eIF-3 p48, Mammary tumor-associated protein INT-6, Viral integration site protein INT-6, eukaryotic translation initiation factor 3 subunit 6, Eukaryotic translation initiation factor 3 subunit 6

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60228 EIF3E

Gene Names

EIF3E, EIF3S6, INT6

Chain

initiator methionine:, chain:2-445

Reference Genes

BioGPS Gene:3646 EIF3E

COSMIC (genes):EIF3E EIF3E

CTD Gene:3646 EIF3E

dbSNP Gene:3646 EIF3E

ENSEMBL:ENSG00000104408 EIF3E

HGNC:3277 EIF3E

KEGG:hsa:3646 EIF3E

Monarch:3646 EIF3E

NCBI Gene:3646 EIF3E

OMIM:602210 EIF3E

UCSC:P60228 EIF3E

Reference Transcript

RefSeq:NM_001568.2 EIF3E

Other Identifiers

11727794_s_at

11727795_x_at

17080116

208697_PM_s_at

208697_s_at

235429_PM_at

235429_at

236989_PM_at

236989_at

2513325

2584751

2913496

3148605

3148606

3148607

3148608

3148609

3148610

3148611

3148612

3148613

3148618

3148619

3148620

3148627

3148628

3148629

3148630

3148631

3148632

3148633

3148634

3148635

3148636

3148638

3148639

3148640

3148641

3148642

3148643

3148644

3148645

3148649

3148654

3148655

3148656

3148661

3148662

3148663

3148664

3148665

3148666

3148679

3646

38681_at

43843_s_at

59102_at

59337_at

61054_at

67157_at

78729_at

8152323

A_23_P43141

A_24_P206427

A_33_P3339885

GE592124

GE629479

GE79095

GO:0000184

GO:0000785

GO:0001732

GO:0002183

GO:0003723

GO:0003743

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005852

GO:0006412

GO:0006413

GO:0006446

GO:0014069

GO:0016020

GO:0016071

GO:0016282

GO:0016605

GO:0032991

GO:0033290

GO:0043226

GO:0045182

GO:0045296

GO:0045727

GO:0045947

GO:0065003

GO:0070062

GO:0071540

GO:1902416

HMNXSV003001144

HMNXSV003054543

Hs.161623.0.A1_3p_at

Hs.293171.0.A1_3p_at

ILMN_1739257

PH_hs_0030043

TC08001524.hg

U62962_at

g12653884_3p_s_at

Participates

as a component of

eIF3 subunits complex [cytosol] (Homo sapiens)

Inferred To

eIF3e [cytosol] (Drosophila melanogaster)

EIF3E [cytosol] (Bos taurus)

EIF3E [cytosol] (Canis familiaris)

EIF3E [cytosol] (Gallus gallus)

EIF3E [cytosol] (Plasmodium falciparum)

EIF3E [cytosol] (Sus scrofa)

Eif3e [cytosol] (Mus musculus)

Eif3e [cytosol] (Rattus norvegicus)

Ghost homologue of EIF3E [cytosol] (Saccharomyces cerevisiae)

eif3e [cytosol] (Xenopus tropicalis)

eif3ea [cytosol] (Danio rerio)

eif3E [cytosol] (Dictyostelium discoideum)

int6 [cytosol] (Schizosaccharomyces pombe)

eif-3.E [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001559.1

ENSEMBL

ENST00000220849, ENSP00000220849

OpenTargets

ENSG00000104408

HPA

ENSG00000104408-EIF3E

PRO

P60228

Pharos - Targets

P60228

GlyGen

P60228

PDB

7QP7, 6ZON, 3J8C, 3J8B, 6YBD, 8OZ0, 7A09, 6ZMW, 6FEC, 6ZP4, 7QP6, 8PPL, 8XXN, 6ZVJ

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.669	4
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.64	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	10
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.602	7
UniProt:Q99814 EPAS1 (HIF2A)	5	EPAS1 [cytosol] (R-HSA-1234119) EPAS1 [nucleoplasm] (R-HSA-452560) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) HN-EPAS1 [cytosol] (R-HSA-1234112)	0.602	10
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) PRKCA [plasma membrane] (R-HSA-156469) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.499	2

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