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43S complex [cytosol]
Stable Identifier
R-HSA-72571
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3:eIGF1A:40S:Met-tRNAi:eIF2:GTP
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
Participants
components
40S ribosomal complex [cytosol]
(Homo sapiens)
EIF1AX [cytosol]
(Homo sapiens)
eIF3 subunits complex [cytosol]
(Homo sapiens)
ternary complex [cytosol]
(Homo sapiens)
Participates
as an output of
Formation of the 43S pre-initiation complex (Homo sapiens)
as a component of
48S complex [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
as an input of
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
Inferred To
43S complex [cytosol]
(Bos taurus)
43S complex [cytosol]
(Caenorhabditis elegans)
43S complex [cytosol]
(Canis familiaris)
43S complex [cytosol]
(Danio rerio)
43S complex [cytosol]
(Dictyostelium discoideum)
43S complex [cytosol]
(Drosophila melanogaster)
43S complex [cytosol]
(Gallus gallus)
43S complex [cytosol]
(Mus musculus)
43S complex [cytosol]
(Plasmodium falciparum)
43S complex [cytosol]
(Rattus norvegicus)
43S complex [cytosol]
(Saccharomyces cerevisiae)
43S complex [cytosol]
(Schizosaccharomyces pombe)
43S complex [cytosol]
(Sus scrofa)
43S complex [cytosol]
(Xenopus tropicalis)
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