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EIF4A1 [cytosol]
Stable Identifier
R-HSA-72573
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4A-I, eIF4AI, eIF-4A-I, eukaryotic initiation factor 4A-I, Eukaryotic initiation factor 4A-I
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
M-decay: degradation of maternal mRNAs by maternally stored factors (Homo sapiens)
BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:deadenylated mRNP [cytosol] (Homo sapiens)
deadenylated mRNP regulated by BTG4 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Z-decay: degradation of maternal mRNAs by zygotically expressed factors (Homo sapiens)
DIS3L2 binds PABPN1 in PABPN1:uridylated mRNA complex (Homo sapiens)
DIS3L2:PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
DIS3L2 hydrolyzes uridylated mRNA (Homo sapiens)
DIS3L2:PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
PABPN1 binds oligouridylated mRNA (Homo sapiens)
PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
TUT4,TUT7 oligouridylate mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)
EIF4F [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F:mRNA [cytosol] (Homo sapiens)
EIF4F [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Translatable mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
TUT4,TUT7 oligouridylate mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Formation of the cap-binding eIF4F complex (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F binds to mRNP (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60842 EIF4A1
Gene Names
EIF4A1, DDX2A, EIF4A
Chain
initiator methionine:, chain:2-406
Reference Genes
BioGPS Gene:1973 EIF4A1
COSMIC (genes):EIF4A1 EIF4A1
CTD Gene:1973 EIF4A1
dbSNP Gene:1973 EIF4A1
ENSEMBL:ENSG00000161960 EIF4A1
HGNC:3282 EIF4A1
KEGG:hsa:1973 EIF4A1
Monarch:1973 EIF4A1
NCBI Gene:1973 EIF4A1
OMIM:602641 EIF4A1
UCSC:P60842 EIF4A1
Reference Transcript
RefSeq:NM_001204510.1 EIF4A1
RefSeq:NM_001416.3 EIF4A1
Other Identifiers
11743120_s_at
11748875_a_at
11751318_s_at
11751319_x_at
11761396_at
11762280_a_at
11762854_a_at
11763556_at
1199_at
16830573
16830575
17119056
1973
201530_PM_x_at
201530_x_at
211787_PM_s_at
211787_s_at
214805_PM_at
214805_at
3060377
3415800
3415801
3415804
3509877
3509879
36234_at
3708827
3708828
3708829
3708830
3708831
3708832
3708833
3708834
3708835
3708836
3708837
3708838
3708839
3708840
3708841
3708842
3708843
3708844
3708845
3708846
3708847
3708848
3708849
3708850
3708851
3708852
3708853
3708854
3708855
3708856
3708857
3708859
3708860
4014659
72074_at
8004497
8004506
8004508
80396_at
A_14_P107097
A_21_P0000278
A_21_P0000295
A_21_P0000300
A_23_P137103
A_24_P390793
D13748_at
GE57074
GE85930
GO:0000339
GO:0002183
GO:0003676
GO:0003723
GO:0003724
GO:0003725
GO:0003729
GO:0003743
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006412
GO:0006413
GO:0008135
GO:0016020
GO:0016281
GO:0016787
GO:0016887
GO:0043226
GO:0045182
GO:0045944
GO:0048471
GO:0070062
GO:0097165
GO:0140098
GO:0140657
HMNXSV003007190
HMNXSV003007847
HMNXSV003016964
HMNXSV003024334
HMNXSV003028969
Hs.239483.0.S1_3p_at
ILMN_1722900
PH_hs_0029165
RNA33433|snoRNA_scaRNA_29_148
RNA33450|snoRNA_scaRNA_46_137
RNA33479|snoRNA_scaRNA_75_135
TC17000101.hg
TC17000102.hg
TC17002867.hg
U79273_at
g4503528_3p_s_at
p33466
Participates
as a component of
eIF4A subunits complex [cytosol] (Homo sapiens)
as a member of
eIF4A [cytosol] (Homo sapiens)
Inferred To
Eif4a1 [cytosol]
(Mus musculus)
Eif4a1 [cytosol]
(Rattus norvegicus)
EIF4A1 [cytosol]
(Bos taurus)
EIF4A1 [cytosol]
(Caenorhabditis elegans)
EIF4A1 [cytosol]
(Canis familiaris)
EIF4A1 [cytosol]
(Drosophila melanogaster)
EIF4A1 [cytosol]
(Plasmodium falciparum)
EIF4A1 [cytosol]
(Saccharomyces cerevisiae)
EIF4A1 [cytosol]
(Schizosaccharomyces pombe)
EIF4A1 [cytosol]
(Sus scrofa)
eif4a1b [cytosol]
(Danio rerio)
Ghost homologue of EIF4A1 [cytosol]
(Gallus gallus)
Ghost homologue of EIF4A1 [cytosol]
(Xenopus tropicalis)
ifdA [cytosol]
(Dictyostelium discoideum)
Cross References
OpenTargets
ENSG00000161960
ENSEMBL
ENST00000577269
,
ENSP00000463486
,
ENSG00000161960
,
ENSP00000293831
,
ENST00000293831
ZINC - Substances
IF4A1_HUMAN
ZINC target
P60842
ZINC - Biogenic
IF4A1_HUMAN
PRO
P60842
GlyGen
P60842
PDB
7PQ0
,
5ZC9
,
8OZ0
,
2ZU6
,
9BLN
,
3EIQ
,
6ZMW
,
5ZBZ
,
8XXN
,
9AVR
,
8HUJ
,
7PPZ
,
2G9N
HPA
ENSG00000161960-EIF4A1
GeneCards
EIF4A1
Pharos - Targets
P60842
ZINC - Predictions - Purchasable
IF4A1_HUMAN
HMDB Protein
HMDBP11793
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04637 EIF4G1
2
EIF4G1 [cytosol]
(R-HSA-72584)
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
0.964
17
UniProt:Q53EL6 PDCD4
1
PDCD4 [cytosol]
(R-HSA-5432887)
0.93
11
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.802
5
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
10
UniProt:Q15056 EIF4H
1
EIF4H [cytosol]
(R-HSA-72591)
0.544
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.527
3
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.527
3
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.527
2
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