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EIF4A1 [cytosol]
Stable Identifier
R-HSA-72573
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4A-I, eIF4AI, eIF-4A-I, eukaryotic initiation factor 4A-I, Eukaryotic initiation factor 4A-I
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)
EIF4F [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F:mRNA [cytosol] (Homo sapiens)
EIF4F [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Translatable mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Formation of the cap-binding eIF4F complex (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F binds to mRNP (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60842 EIF4A1
Gene Names
EIF4A1, DDX2A, EIF4A
Chain
initiator methionine:1, chain:2-406
Reference Genes
BioGPS Gene:1973 EIF4A1
COSMIC (genes):EIF4A1 EIF4A1
CTD Gene:1973 EIF4A1
dbSNP Gene:1973 EIF4A1
ENSEMBL:ENSG00000161960.16 EIF4A1
HGNC:3282 EIF4A1
KEGG Gene (Homo sapiens):1973 EIF4A1
Monarch:1973 EIF4A1
NCBI Gene:1973 EIF4A1
OMIM:602641 EIF4A1
UCSC:P60842 EIF4A1
Reference Transcript
RefSeq:NM_001204510.1 EIF4A1
RefSeq:NM_001416.3 EIF4A1
Other Identifiers
0001660066
11743120_s_at
11751318_s_at
11751319_x_at
1199_at
1973
201530_PM_x_at
201530_x_at
211787_PM_s_at
211787_s_at
3060377
3415800
3415801
3415804
3509877
3509879
3708831
3708833
3708837
3708838
3708840
3708842
3708844
3708845
3708847
3708849
3708853
3708855
3708856
3708857
4014659
72074_at
8004497
80396_at
A_23_P137103
A_24_P390793
D13748_at
GE57074
GE85930
GO:0000166
GO:0000339
GO:0002181
GO:0002183
GO:0003676
GO:0003723
GO:0003724
GO:0003725
GO:0003729
GO:0003743
GO:0004386
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0006412
GO:0006413
GO:0008135
GO:0016020
GO:0016281
GO:0016787
GO:0016887
GO:0032991
GO:0043226
GO:0045182
GO:0070062
GO:0140098
GO:0140657
HMNXSV003007847
HMNXSV003016964
ILMN_1722900
ILMN_3251629
PH_hs_0029165
TC17002867.hg
g4503528_3p_s_at
p33466
Participates
as a member of
eIF4A [cytosol] (Homo sapiens)
as a component of
eIF4A subunits complex [cytosol] (Homo sapiens)
Inferred To
Eif4a1 [cytosol]
(Rattus norvegicus)
EIF4A1 [cytosol]
(Bos taurus)
EIF4A1 [cytosol]
(Caenorhabditis elegans)
EIF4A1 [cytosol]
(Canis familiaris)
EIF4A1 [cytosol]
(Danio rerio)
EIF4A1 [cytosol]
(Drosophila melanogaster)
EIF4A1 [cytosol]
(Mus musculus)
EIF4A1 [cytosol]
(Plasmodium falciparum)
EIF4A1 [cytosol]
(Saccharomyces cerevisiae)
EIF4A1 [cytosol]
(Schizosaccharomyces pombe)
EIF4A1 [cytosol]
(Sus scrofa)
Ghost homologue of EIF4A1 [cytosol]
(Gallus gallus)
Ghost homologue of EIF4A1 [cytosol]
(Xenopus tropicalis)
ifdA [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001191439.1
,
NP_001407.1
OpenTargets
ENSG00000161960
ZINC - Substances
IF4A1_HUMAN
ZINC target
P60842
ZINC - Biogenic
IF4A1_HUMAN
PRO
P60842
PDB
2G9N
,
7PQ0
,
2ZU6
,
3EIQ
,
7PPZ
,
5ZBZ
,
6ZMW
,
5ZC9
IntEnz
3.6.4.13
HPA
ENSG00000161960-EIF4A1
GeneCards
P60842
Ensembl
ENSG00000161960
,
ENSP00000463486
,
ENST00000577269
,
ENSP00000293831
,
ENST00000293831
Pharos - Targets
P60842
ZINC - Predictions - Purchasable
IF4A1_HUMAN
HMDB Protein
HMDBP11793
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04637 EIF4G1
2
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
EIF4G1 [cytosol]
(R-HSA-72584)
0.961
15
UniProt:Q53EL6 PDCD4
1
PDCD4 [cytosol]
(R-HSA-5432887)
0.901
10
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.669
3
UniProt:Q15056 EIF4H
1
EIF4H [cytosol]
(R-HSA-72591)
0.544
2
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
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