Reactome | EIF4A1 [cytosol]

EIF4A1 [cytosol]

Stable Identifier

R-HSA-72573

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF4A-I, eIF4AI, eIF-4A-I, eukaryotic initiation factor 4A-I, Eukaryotic initiation factor 4A-I

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External Reference Information

External Reference

UniProt:P60842 EIF4A1

Gene Names

EIF4A1, DDX2A, EIF4A

Chain

initiator methionine:, chain:2-406

Reference Genes

BioGPS Gene:1973 EIF4A1

COSMIC (genes):EIF4A1 EIF4A1

CTD Gene:1973 EIF4A1

dbSNP Gene:1973 EIF4A1

ENSEMBL:ENSG00000161960 EIF4A1

HGNC:3282 EIF4A1

KEGG:hsa:1973 EIF4A1

Monarch:1973 EIF4A1

NCBI Gene:1973 EIF4A1

OMIM:602641 EIF4A1

UCSC:P60842 EIF4A1

Reference Transcript

Other Identifiers

11743120_s_at

11748875_a_at

11751318_s_at

11751319_x_at

11761396_at

11762280_a_at

11762854_a_at

11763556_at

1199_at

16830573

16830575

17119056

1973

201530_PM_x_at

201530_x_at

211787_PM_s_at

211787_s_at

214805_PM_at

214805_at

3060377

3415800

3415801

3415804

3509877

3509879

36234_at

3708827

3708828

3708829

3708830

3708831

3708832

3708833

3708834

3708835

3708836

3708837

3708838

3708839

3708840

3708841

3708842

3708843

3708844

3708845

3708846

3708847

3708848

3708849

3708850

3708851

3708852

3708853

3708854

3708855

3708856

3708857

3708859

3708860

4014659

72074_at

8004497

8004506

8004508

80396_at

A_14_P107097

A_21_P0000278

A_21_P0000295

A_21_P0000300

A_23_P137103

A_24_P390793

D13748_at

GE57074

GE85930

GO:0000339

GO:0002183

GO:0003676

GO:0003723

GO:0003724

GO:0003725

GO:0003729

GO:0003743

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006412

GO:0006413

GO:0008135

GO:0016020

GO:0016281

GO:0016787

GO:0016887

GO:0043226

GO:0045182

GO:0045944

GO:0048471

GO:0070062

GO:0097165

GO:0140098

GO:0140657

HMNXSV003007190

HMNXSV003007847

HMNXSV003016964

HMNXSV003024334

HMNXSV003028969

Hs.239483.0.S1_3p_at

ILMN_1722900

PH_hs_0029165

RNA33433|snoRNA_scaRNA_29_148

RNA33450|snoRNA_scaRNA_46_137

RNA33479|snoRNA_scaRNA_75_135

TC17000101.hg

TC17000102.hg

TC17002867.hg

U79273_at

g4503528_3p_s_at

p33466

Participates

as a component of

eIF4A subunits complex [cytosol] (Homo sapiens)

as a member of

eIF4A [cytosol] (Homo sapiens)

Inferred To

Eif4a1 [cytosol] (Mus musculus)

Eif4a1 [cytosol] (Rattus norvegicus)

EIF4A1 [cytosol] (Bos taurus)

EIF4A1 [cytosol] (Caenorhabditis elegans)

EIF4A1 [cytosol] (Canis familiaris)

EIF4A1 [cytosol] (Drosophila melanogaster)

EIF4A1 [cytosol] (Plasmodium falciparum)

EIF4A1 [cytosol] (Saccharomyces cerevisiae)

EIF4A1 [cytosol] (Schizosaccharomyces pombe)

EIF4A1 [cytosol] (Sus scrofa)

eif4a1b [cytosol] (Danio rerio)

Ghost homologue of EIF4A1 [cytosol] (Gallus gallus)

Ghost homologue of EIF4A1 [cytosol] (Xenopus tropicalis)

ifdA [cytosol] (Dictyostelium discoideum)

Cross References

OpenTargets

ENSG00000161960

ENSEMBL

ENST00000577269, ENSP00000463486, ENSG00000161960, ENSP00000293831, ENST00000293831

ZINC - Substances

IF4A1_HUMAN

ZINC target

P60842

ZINC - Biogenic

IF4A1_HUMAN

PRO

P60842

GlyGen

P60842

PDB

7PQ0, 5ZC9, 8OZ0, 2ZU6, 9BLN, 3EIQ, 6ZMW, 5ZBZ, 8XXN, 9AVR, 8HUJ, 7PPZ, 2G9N

HPA

ENSG00000161960-EIF4A1

GeneCards

EIF4A1

Pharos - Targets

P60842

ZINC - Predictions - Purchasable

IF4A1_HUMAN

HMDB Protein

HMDBP11793

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04637 EIF4G1	2	EIF4G1 [cytosol] (R-HSA-72584) p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762)	0.964	17
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.93	11
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.802	5
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	10
UniProt:Q15056 EIF4H	1	EIF4H [cytosol] (R-HSA-72591)	0.544	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	3
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2

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