Reactome | EIF4A1 [cytosol]

EIF4A1 [cytosol]

Stable Identifier

R-HSA-72573

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF4A-I, eIF4AI, eIF-4A-I, eukaryotic initiation factor 4A-I, Eukaryotic initiation factor 4A-I

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External Reference Information

External Reference

UniProt:P60842 EIF4A1

Gene Names

EIF4A1, DDX2A, EIF4A

Chain

initiator methionine:1, chain:2-406

Reference Genes

BioGPS Gene:1973 EIF4A1

COSMIC (genes):EIF4A1 EIF4A1

CTD Gene:1973 EIF4A1

dbSNP Gene:1973 EIF4A1

ENSEMBL:ENSG00000161960.16 EIF4A1

HGNC:3282 EIF4A1

KEGG Gene (Homo sapiens):1973 EIF4A1

Monarch:1973 EIF4A1

NCBI Gene:1973 EIF4A1

OMIM:602641 EIF4A1

UCSC:P60842 EIF4A1

Reference Transcript

Other Identifiers

0001660066

11743120_s_at

11751318_s_at

11751319_x_at

1199_at

1973

201530_PM_x_at

201530_x_at

211787_PM_s_at

211787_s_at

3060377

3415800

3415801

3415804

3509877

3509879

3708831

3708833

3708837

3708838

3708840

3708842

3708844

3708845

3708847

3708849

3708853

3708855

3708856

3708857

4014659

72074_at

8004497

80396_at

A_23_P137103

A_24_P390793

D13748_at

GE57074

GE85930

GO:0000166

GO:0000339

GO:0002181

GO:0002183

GO:0003676

GO:0003723

GO:0003724

GO:0003725

GO:0003729

GO:0003743

GO:0004386

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0006412

GO:0006413

GO:0008135

GO:0016020

GO:0016281

GO:0016787

GO:0016887

GO:0032991

GO:0043226

GO:0045182

GO:0070062

GO:0140098

GO:0140657

HMNXSV003007847

HMNXSV003016964

ILMN_1722900

ILMN_3251629

PH_hs_0029165

TC17002867.hg

g4503528_3p_s_at

p33466

Participates

as a member of

eIF4A [cytosol] (Homo sapiens)

as a component of

eIF4A subunits complex [cytosol] (Homo sapiens)

Inferred To

Eif4a1 [cytosol] (Rattus norvegicus)

EIF4A1 [cytosol] (Bos taurus)

EIF4A1 [cytosol] (Caenorhabditis elegans)

EIF4A1 [cytosol] (Canis familiaris)

EIF4A1 [cytosol] (Danio rerio)

EIF4A1 [cytosol] (Drosophila melanogaster)

EIF4A1 [cytosol] (Mus musculus)

EIF4A1 [cytosol] (Plasmodium falciparum)

EIF4A1 [cytosol] (Saccharomyces cerevisiae)

EIF4A1 [cytosol] (Schizosaccharomyces pombe)

EIF4A1 [cytosol] (Sus scrofa)

Ghost homologue of EIF4A1 [cytosol] (Gallus gallus)

Ghost homologue of EIF4A1 [cytosol] (Xenopus tropicalis)

ifdA [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001191439.1, NP_001407.1

OpenTargets

ENSG00000161960

ZINC - Substances

IF4A1_HUMAN

ZINC target

P60842

ZINC - Biogenic

IF4A1_HUMAN

PRO

P60842

PDB

2G9N, 7PQ0, 2ZU6, 3EIQ, 7PPZ, 5ZBZ, 6ZMW, 5ZC9

IntEnz

3.6.4.13

HPA

ENSG00000161960-EIF4A1

GeneCards

P60842

Ensembl

ENSG00000161960, ENSP00000463486, ENST00000577269, ENSP00000293831, ENST00000293831

Pharos - Targets

P60842

ZINC - Predictions - Purchasable

IF4A1_HUMAN

HMDB Protein

HMDBP11793

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.961	15
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.901	10
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.669	3
UniProt:Q15056 EIF4H	1	EIF4H [cytosol] (R-HSA-72591)	0.544	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4

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