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EIF4E [cytosol]
Stable Identifier
R-HSA-72578
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4E, eIF-4F 25 kDa subunit, eukaryotic translation initiation factor 4E, mRNA cap-binding protein, Eukaryotic translation initiation factor 4E, eIF-4E
Icon
Locations in the PathwayBrowser for interactor UniProt:Q5T124 UBXN11
Expand all
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
Transport of the SLBP Dependant Mature mRNA (Homo sapiens)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Formation of the cap-binding eIF4F complex (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
Release of eIF4E from the inactive eIF4E:4E-BP complex (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06730 EIF4E
Gene Names
EIF4E, EIF4EL1, EIF4F
Chain
initiator methionine:1, chain:2-217
Reference Genes
BioGPS Gene:1977 EIF4E
COSMIC (genes):EIF4E EIF4E
CTD Gene:1977 EIF4E
dbSNP Gene:1977 EIF4E
ENSEMBL:ENSG00000151247 EIF4E
HGNC:3287 EIF4E
KEGG Gene (Homo sapiens):1977 EIF4E
Monarch:1977 EIF4E
NCBI Gene:1977 EIF4E
OMIM:133440 EIF4E
UCSC:P06730 EIF4E
Reference Transcript
RefSeq:NM_001130679.2 EIF4E
RefSeq:NM_001331017.1 EIF4E
RefSeq:NM_001968.4 EIF4E
RefSeq:NM_001130678.2 EIF4E
Other Identifiers
0006520440
11732130_x_at
11736166_s_at
11741416_s_at
11741417_x_at
11758512_s_at
1977
201435_s_at
201436_3p_at
201436_at
201437_s_at
2779004
2779005
2779006
2779007
2779008
2779009
2779010
2779011
2779012
2779014
2779015
2779017
2779027
2779039
3087021
3761830
3761831
3761832
37752_at
56158_r_at
73201_at
A_23_P118643
A_23_P118649
A_32_P203300
GE57839
GO:0000082
GO:0000278
GO:0000339
GO:0000340
GO:0000932
GO:0001662
GO:0003674
GO:0003723
GO:0003743
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005845
GO:0006405
GO:0006406
GO:0006412
GO:0006413
GO:0006417
GO:0006810
GO:0006913
GO:0006950
GO:0007049
GO:0007267
GO:0008134
GO:0008135
GO:0008150
GO:0009058
GO:0010494
GO:0015031
GO:0016032
GO:0016281
GO:0016442
GO:0017148
GO:0019827
GO:0019899
GO:0030154
GO:0030324
GO:0031370
GO:0032991
GO:0033391
GO:0034641
GO:0036464
GO:0043226
GO:0044403
GO:0045182
GO:0045665
GO:0045931
GO:0048471
GO:0048856
GO:0070062
GO:0070491
GO:0071549
GO:0098794
GO:0098978
GO:0099524
GO:0099578
HMNXSV003040115
HMNXSV003042746
Hs.79306.0.A1_3p_a_at
Hs.79306.0.A3_3p_at
Hs.79306.0.A3_3p_x_at
ILMN_1658955
ILMN_2050761
ILMN_3250077
ILMN_3250927
M15353_at
PH_hs_0004585
g4503534_3p_a_at
g4503534_3p_x_at
Participates
as a member of
EIF4E1/EIF4E3 [cytosol] (Homo sapiens)
as a component of
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
Translatable mRNA Complex [cytosol] (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4E:4E-BP1-P [cytosol] (Homo sapiens)
Mature Intronless Transcript Derived mRNA:eIF4E Complex [cytosol] (Homo sapiens)
Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex [cytosol] (Homo sapiens)
Mature SLBP independent Histone mRNA:eIF4E complex [cytosol] (Homo sapiens)
eIF4E:4E-BP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
as an output of
PARN deadenylates mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)
Release of eIF4E from the inactive eIF4E:4E-BP complex (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
as an input of
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)
Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)
Formation of the cap-binding eIF4F complex (Homo sapiens)
Inferred To
Eif4e [cytosol]
(Mus musculus)
Eif4e [cytosol]
(Rattus norvegicus)
eIF4E1 [cytosol]
(Drosophila melanogaster)
ife-3 [cytosol]
(Caenorhabditis elegans)
eif4e [cytosol]
(Dictyostelium discoideum)
eif4e [cytosol]
(Xenopus tropicalis)
EIF4E [cytosol]
(Bos taurus)
EIF4E [cytosol]
(Canis familiaris)
EIF4E [cytosol]
(Gallus gallus)
EIF4E [cytosol]
(Plasmodium falciparum)
EIF4E [cytosol]
(Sus scrofa)
tif452 [cytosol]
(Schizosaccharomyces pombe)
CDC33 [cytosol]
(Saccharomyces cerevisiae)
eif4eb [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001959.1
,
NP_001124151.1
,
NP_001124150.1
,
NP_001317946.1
ZINC - World Drugs
IF4E_HUMAN
OpenTargets
ENSG00000151247
ZINC - FDA approved
IF4E_HUMAN
ZINC - Substances
IF4E_HUMAN
ZINC target
P06730
PRO
P06730
GlyGen
P06730
PDB
5GW6
,
5EI3
,
7D6Y
,
5ZK9
,
4UED
,
5ZK7
,
3AM7
,
4BEA
,
4DUM
,
5T46
,
4AZA
,
2V8Y
,
2W97
,
5ZML
,
3TF2
,
2V8W
,
2V8X
,
5EIR
,
3U7X
,
1IPB
,
7MEU
,
4TQB
,
1IPC
,
2GPQ
,
4TPW
,
4DT6
,
5ZJZ
,
5ZK5
,
1WKW
,
5EKV
,
7D8B
,
5ZJY
,
5EHC
,
4TQC
HPA
ENSG00000151247-EIF4E
GeneCards
P06730
Ensembl
ENSG00000151247
,
ENST00000505992
,
ENSP00000425561
,
ENSP00000389624
,
ENSP00000280892
,
ENST00000450253
,
ENST00000280892
Pharos - Targets
P06730
ZINC - Predictions - Purchasable
IF4E_HUMAN
Orphanet
18985
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13541 EIF4EBP1
2
EIF4EBP1 [cytosol]
(R-HSA-72580)
p-T37,T46-EIF4EBP1 [cytosol]
(R-HSA-165685)
0.981
32
UniProt:Q13542 4EBP2
0.956
14
UniProt:Q9NRA8 4ET
0.942
12
UniProt:Q04637 EIF4G1
2
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
EIF4G1 [cytosol]
(R-HSA-72584)
0.915
10
UniProt:O60516 4EBP3
0.896
11
UniProt:Q63ZY3 KANK2
0.781
7
UniProt:O00571 DDX3X
3
DDX3X [secretory granule lumen]
(R-HSA-6801275)
DDX3X [extracellular region]
(R-HSA-6806507)
DDX3X [ficolin-1-rich granule lumen]
(R-HSA-6801273)
0.775
7
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.742
5
UniProt:O43432 EIF4G3
1
EIF4G3 [cytosol]
(R-HSA-1678827)
0.688
3
UniProt:P60842 EIF4A1
1
EIF4A1 [cytosol]
(R-HSA-72573)
0.669
3
UniProt:P48775 TDO2
1
TDO2 [cytosol]
(R-HSA-71184)
0.666
4
ChEBI:50210 7-METHYL-GTP
0.643
4
UniProt:O43432-1 EIF4G3
0.623
2
UniProt:Q04743 EMX2
0.591
4
UniProt:Q8TEQ6 GEMIN5
2
GEMIN5 [nucleoplasm]
(R-HSA-191765)
GEMIN5 [cytosol]
(R-HSA-191833)
0.582
3
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.576
6
UniProt:O15372 EIF3H
1
EIF3H [cytosol]
(R-HSA-72544)
0.564
2
UniProt:Q14240 EIF4A2
1
EIF4A2 [cytosol]
(R-HSA-72575)
0.564
2
UniProt:O73557 Z
0.558
3
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.558
5
UniProt:Q5T124 UBXN11
1
UBXN11 [cytosol]
(R-HSA-9696514)
0.556
3
UniProt:P03427 PB2
0.547
2
UniProt:P55884 EIF3B
1
EIF3B [cytosol]
(R-HSA-72542)
0.527
7
UniProt:P62753 RPS6
3
RPS6 [nucleoplasm]
(R-HSA-6790606)
p-5S-RPS6 [cytosol]
(R-HSA-165727)
RPS6 [cytosol]
(R-HSA-72381)
0.527
2
UniProt:Q9UNK9 ANGE1
0.527
2
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
0.524
2
UniProt:Q60809
1
Cnot7 [cytosol]
(R-MMU-429877)
0.499
2
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.462
3
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