Formation of the 43S pre-initiation complex

Stable Identifier
R-HSA-72691
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Formation of the 43S pre-initiation complex
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The ternary complex (Met-tRNAi:eIF2:GTP) binds to the complex formed by the 40S subunit, eIF3 and eIF1A, to form the 43S complex. eIF1A promotes binding of the ternary complex to the 40S subunit within 43S. The initiator methionyl-tRNA from the ternary complex is positioned at the ribosomal P site.
Literature References
PubMed ID Title Journal Year
592399 Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.

Erni, B, Schreier, MH, Trachsel, H, Staehelin, T

J Mol Biol 1978
641056 The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.

Benne, R, Hershey, JW

J Biol Chem 1978
  Post-Transcriptional Control of Gene Expression

McCarthy, JE, Tuite, M

  1990
429297 Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation.

Safer, B, Peterson, DT, Merrick, WC

J Biol Chem 1979
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Orthologous Events
Formation of the 43S pre-initiation complex (Bos taurus)
Formation of the 43S pre-initiation complex (Caenorhabditis elegans)
Formation of the 43S pre-initiation complex (Canis familiaris)
Formation of the 43S pre-initiation complex (Danio rerio)
Formation of the 43S pre-initiation complex (Dictyostelium discoideum)
Formation of the 43S pre-initiation complex (Drosophila melanogaster)
Formation of the 43S pre-initiation complex (Gallus gallus)
Formation of the 43S pre-initiation complex (Mus musculus)
Formation of the 43S pre-initiation complex (Plasmodium falciparum)
Formation of the 43S pre-initiation complex (Rattus norvegicus)
Formation of the 43S pre-initiation complex (Saccharomyces cerevisiae)
Formation of the 43S pre-initiation complex (Schizosaccharomyces pombe)
Formation of the 43S pre-initiation complex (Sus scrofa)
Formation of the 43S pre-initiation complex (Xenopus tropicalis)
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