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Recycling of eIF2:GDP
Stable Identifier
R-HSA-72731
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
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The active eIF2:GTP complex may be formed by direct binding of GTP to free eIF2 or by GDP-GTP exchange on the eIF2:GDP:eIF2B complex. The eIF2:GDP complex binds eIF2B forming an eIF2:GDP:eIF2B intermediate complex. eIF2B is a guanine nucleotide releasing factor required to cause GDP release so that a new GTP molecule can bind and activate eIF2. Phosphorylated eIF2:GDP sequesters all eIF2B as an inactive complex, and thus, reuse of eIF2 is inhibited as a consequence of the tight bond it forms with eIF2B, which prevents nucleotide exchange. Therefore, in the absence of free eIF2B, excess eIF2 remains in its inactive GDP-bound form and protein synthesis slows dramatically.
Literature References
PubMed ID
Title
Journal
Year
7063012
Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2.
Clemens, MJ
,
Pain, VM
,
Henshaw, EC
,
Wong, ST
Nature
1982
Participants
Events
Formation of eIF2:GDP:eIF2B intermediate
(Homo sapiens)
eIF2 activation
(Homo sapiens)
Participates
as an event of
Cap-dependent Translation Initiation (Homo sapiens)
Orthologous Events
Recycling of eIF2:GDP (Bos taurus)
Recycling of eIF2:GDP (Caenorhabditis elegans)
Recycling of eIF2:GDP (Canis familiaris)
Recycling of eIF2:GDP (Danio rerio)
Recycling of eIF2:GDP (Dictyostelium discoideum)
Recycling of eIF2:GDP (Drosophila melanogaster)
Recycling of eIF2:GDP (Gallus gallus)
Recycling of eIF2:GDP (Mus musculus)
Recycling of eIF2:GDP (Plasmodium falciparum)
Recycling of eIF2:GDP (Rattus norvegicus)
Recycling of eIF2:GDP (Saccharomyces cerevisiae)
Recycling of eIF2:GDP (Schizosaccharomyces pombe)
Recycling of eIF2:GDP (Sus scrofa)
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