Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene SLC29A4 encodes the equilibrative nucleoside transporter 4 (ENT4). It is ubiquitously expressed and mediates the reversible transport of the nucleoside adenosine at acidic pH (this transport is absent at pH 7.4) (Barnes K et al, 2006). ENT4 has also been shown to mediate the transport of biogenic amines such as serotonin, dopamine, norepinephrine and epinephrine. For this reason, ENT4 is also known as the plasma membrane monoamine transporter (PMAT) (Engel K et al, 2004).

Literature References
PubMed ID Title Journal Year
16873718 Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH

Ritzel, MW, Boyett, MR, Foppolo, S, Beal, PR, Baldwin, SA, Barnes, K, Billeter-Clark, R, Young, JD, Sun, L, Scullion, ER, Dobrzynski, H, Tellez, J, Ismat, F, Cass, CE, Claycomb, WC

Circ Res 2006
15448143 Identification and characterization of a novel monoamine transporter in the human brain

Engel, K, Zhou, M, Wang, J

J Biol Chem 2004
Catalyst Activity

nucleoside transmembrane transporter activity of SLC29A4 [plasma membrane]

Orthologous Events
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