Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4

Stable Identifier
R-HSA-727740
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4
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The human gene SLC29A4 encodes the equilibrative nucleoside transporter 4 (ENT4). It is ubiquitously expressed and mediates the reversible transport of the nucleoside adenosine at acidic pH (this transport is absent at pH 7.4) (Barnes K et al, 2006). ENT4 has also been shown to mediate the transport of biogenic amines such as serotonin, dopamine, norepinephrine and epinephrine. For this reason, ENT4 is also known as the plasma membrane monoamine transporter (PMAT) (Engel K et al, 2004).
Literature References
PubMed ID Title Journal Year
16873718 Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH

Barnes, K, Dobrzynski, H, Foppolo, S, Beal, PR, Ismat, F, Scullion, ER, Sun, L, Tellez, J, Ritzel, MW, Claycomb, WC, Cass, CE, Young, JD, Billeter-Clark, R, Boyett, MR, Baldwin, SA

Circ Res 2006
15448143 Identification and characterization of a novel monoamine transporter in the human brain

Engel, K, Zhou, M, Wang, J

J Biol Chem 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

nucleoside transmembrane transporter activity of SLC29A4 [plasma membrane]

Physical Entity
SLC29A4 [plasma membrane] (Homo sapiens)
Activity
nucleoside transmembrane transporter activity (GO:0005337)
Orthologous Events
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)
Cross References
RHEA
Authored
Jassal, B  (2010-05-12)
Reviewed
He, L  (2010-05-10)
Created
Jassal, B  (2010-05-12)
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