SLC29A3 transports nucleosides from lysosomal lumen to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
Equilibrative transport (export) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3
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The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. SLC29A3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin et al. 2005). Defects in SLC29A3 can cause histiocytosis-lymphadenopathy plus syndrome (HLAS; MIM:602782), an autosomal recessive disorder characterised by combined features from 2 or more of four histiocytic disorders (Molho-Pessach et al. 2008).

Literature References
PubMed ID Title Journal Year
18940313 The H syndrome is caused by mutations in the nucleoside transporter hENT3

Molho-Pessach, V, Elpeleg, O, Lerer, I, Abeliovich, D, Broshtilova, V, Agha, Z, Abu Libdeh, A, Zlotogorski, A

Am J Hum Genet 2008
15701636 Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes

Ritzel, MW, Foppolo, S, Hyde, RJ, Ng, AM, Barnes, K, Baldwin, SA, Young, JD, Cass, CE, Yao, SY

J Biol Chem 2005
Catalyst Activity

nucleoside transmembrane transporter activity of SLC29A3 [lysosomal membrane]

Orthologous Events
Cross References
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