Reactome | SLC35A1 exchanges CMP-Neu5Ac for CMP

SLC35A1 exchanges CMP-Neu5Ac for CMP

Stable Identifier

R-HSA-727807

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen, cytosol

Synonyms

SLC35A1 mediates the antiport of CMP-sialic acid in exchange for CMP

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        SLC35A1 exchanges CMP-Neu5Ac for CMP (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human gene SLC35A1 encodes the CMP-sialic acid transporter which mediates the antiport of CMP-sialic acid (CMP-Neu5Ac) into the Golgi lumen in exchange for CMP (Ishida et al. 1996). Defects in SLC35A1 are the cause of congenital disorder of glycosylation type 2F (CDG2F; MIM:603585). CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation (Martinez-Duncker et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15576474	Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter Mollicone, R, Tchernia, G, Trichet, C, Dupré, T, Oriol, R, Candelier, JJ, Piller, V, Piller, F, Martinez-Duncker, I	Blood	2005
9010752	Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family Ishida, N, Miura, N, Kawakita, M, Yoshioka, S	J Biochem	1996