Reactome | PRPS1 [cytosol]

PRPS1 [cytosol]

Stable Identifier

R-HSA-73483

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phosphoribosyl pyrophosphate synthetase 1, Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PPRibP) (PRS-I), Ribose-phosphate pyrophosphokinase I , Phosphoribosyl pyrophosphate synthetase I, PPRibP, PRS-I

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60891 PRPS1

Gene Names

PRPS1

Chain

initiator methionine:1, chain:2-318

Reference Genes

BioGPS Gene:5631 PRPS1

COSMIC (genes):PRPS1 PRPS1

CTD Gene:5631 PRPS1

dbSNP Gene:5631 PRPS1

ENSEMBL:ENSG00000147224 PRPS1

HGNC:9462 PRPS1

KEGG Gene (Homo sapiens):5631 PRPS1

Monarch:5631 PRPS1

NCBI Gene:5631 PRPS1

OMIM:311850 PRPS1

UCSC:P60891 PRPS1

Reference Transcript

Other Identifiers

0006040717

11717084_a_at

11717085_a_at

17106031

208447_s_at

209440_at

3189073

3189077

36489_at

36490_s_at

3986515

3986516

3986517

3986518

3986521

3986524

3986525

3986527

3986528

3986529

5631

8169240

A_23_P95764

D00860_at

GE57039

GE57982

GO:0000166

GO:0000287

GO:0002189

GO:0003674

GO:0004749

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006015

GO:0006144

GO:0006164

GO:0006221

GO:0007399

GO:0008150

GO:0009058

GO:0009116

GO:0009156

GO:0009165

GO:0016301

GO:0016310

GO:0016740

GO:0032991

GO:0034418

GO:0034641

GO:0042802

GO:0042803

GO:0043167

GO:0044249

GO:0044281

GO:0046101

GO:0046872

GO:0048856

HMNXSV003040263

ILMN_1667050

PH_hs_0000008

TC0X000526.hg

X15331_s_at

g12804406_3p_at

g4506126_3p_a_at

Participates

as a component of

PRPS1 dimer [cytosol] (Homo sapiens)

Inferred To

PRS3 [cytosol] (Saccharomyces cerevisiae)

PRPS1L1 [cytosol] (Gallus gallus)

Homologues of PRPS1 [cytosol] (Danio rerio)

Homologues of PRPS1 [cytosol] (Dictyostelium discoideum)

Homologues of PRPS1 [cytosol] (Plasmodium falciparum)

Homologues of PRPS1 [cytosol] (Saccharomyces cerevisiae)

Homologues of PRPS1 [cytosol] (Schizosaccharomyces pombe)

Prps1 [cytosol] (Mus musculus)

Prps1 [cytosol] (Rattus norvegicus)

prsA [cytosol] (Dictyostelium discoideum)

PRS1 [cytosol] (Saccharomyces cerevisiae)

PRS2 [cytosol] (Saccharomyces cerevisiae)

prps1b [cytosol] (Danio rerio)

prps1a [cytosol] (Danio rerio)

Prps [cytosol] (Drosophila melanogaster)

PRS5 [cytosol] (Saccharomyces cerevisiae)

prsB [cytosol] (Dictyostelium discoideum)

PRS4 [cytosol] (Saccharomyces cerevisiae)

PRPS1 [cytosol] (Bos taurus)

PRPS1 [cytosol] (Caenorhabditis elegans)

PRPS1 [cytosol] (Canis familiaris)

PRPS1 [cytosol] (Plasmodium falciparum)

PRPS1 [cytosol] (Schizosaccharomyces pombe)

PRPS1 [cytosol] (Sus scrofa)

prsC [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001191331.1, NP_002755.1

OpenTargets

ENSG00000147224

GeneCards

P60891

HPA

ENSG00000147224-PRPS1

ZINC target

P60891

Ensembl

ENSP00000361512, ENSG00000147224, ENST00000372435

PRO

P60891

Pharos - Targets

P60891

GlyGen

P60891

Orphanet

15153

HMDB Protein

HMDBP00628

PDB

2H07, 4F8E, 2H08, 2H06, 2HCR, 3S5J, 3EFH, 4LZN, 4LZO, 4M0U, 4LYG, 4M0P

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99967 CITED2	1	CITED2 [nucleoplasm] (R-HSA-6804489)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:Q13569 TDG	3	SUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) SUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) TDG [nucleoplasm] (R-HSA-65812)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O15287 FANCG	1	FANCG [nucleoplasm] (R-HSA-419532)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [nucleoplasm] (R-HSA-3325590) p-S-PER1 [cytosol] (R-HSA-400310) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:A1L190 SYCE3	1	SYCE3 [nucleoplasm] (R-HSA-8867779)	0.556	3

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