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PRPS1 [cytosol]
Stable Identifier
R-HSA-73483
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phosphoribosyl pyrophosphate synthetase 1, Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PPRibP) (PRS-I), Ribose-phosphate pyrophosphokinase I , Phosphoribosyl pyrophosphate synthetase I, PPRibP, PRS-I
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Pentose phosphate pathway (Homo sapiens)
5-Phosphoribose 1-diphosphate biosynthesis (Homo sapiens)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Homo sapiens)
PRPS1 dimer [cytosol] (Homo sapiens)
PRPS1 [cytosol] (Homo sapiens)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Homo sapiens)
PRPS2 dimer, PRPS1L dimer [cytosol] (Homo sapiens)
PRPS1 dimer [cytosol] (Homo sapiens)
PRPS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60891 PRPS1
Gene Names
PRPS1
Chain
initiator methionine:1, chain:2-318
Reference Genes
BioGPS Gene:5631 PRPS1
COSMIC (genes):PRPS1 PRPS1
CTD Gene:5631 PRPS1
dbSNP Gene:5631 PRPS1
ENSEMBL:ENSG00000147224 PRPS1
HGNC:9462 PRPS1
KEGG Gene (Homo sapiens):5631 PRPS1
Monarch:5631 PRPS1
NCBI Gene:5631 PRPS1
OMIM:311850 PRPS1
UCSC:P60891 PRPS1
Reference Transcript
RefSeq:NM_001204402.1 PRPS1
RefSeq:NM_002764.3 PRPS1
Other Identifiers
0006040717
11717084_a_at
11717085_a_at
17106031
208447_s_at
209440_at
3189073
3189077
36489_at
36490_s_at
3986515
3986516
3986517
3986518
3986521
3986524
3986525
3986527
3986528
3986529
5631
8169240
A_23_P95764
D00860_at
GE57039
GE57982
GO:0000166
GO:0000287
GO:0002189
GO:0003674
GO:0004749
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006015
GO:0006144
GO:0006164
GO:0006221
GO:0007399
GO:0008150
GO:0009058
GO:0009116
GO:0009156
GO:0009165
GO:0016301
GO:0016310
GO:0016740
GO:0032991
GO:0034418
GO:0034641
GO:0042802
GO:0042803
GO:0043167
GO:0044249
GO:0044281
GO:0046101
GO:0046872
GO:0048856
HMNXSV003040263
ILMN_1667050
PH_hs_0000008
TC0X000526.hg
X15331_s_at
g12804406_3p_at
g4506126_3p_a_at
Participates
as a component of
PRPS1 dimer [cytosol] (Homo sapiens)
Inferred To
PRS3 [cytosol]
(Saccharomyces cerevisiae)
PRPS1L1 [cytosol]
(Gallus gallus)
Homologues of PRPS1 [cytosol]
(Danio rerio)
Homologues of PRPS1 [cytosol]
(Dictyostelium discoideum)
Homologues of PRPS1 [cytosol]
(Plasmodium falciparum)
Homologues of PRPS1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PRPS1 [cytosol]
(Schizosaccharomyces pombe)
Prps1 [cytosol]
(Mus musculus)
Prps1 [cytosol]
(Rattus norvegicus)
prsA [cytosol]
(Dictyostelium discoideum)
PRS1 [cytosol]
(Saccharomyces cerevisiae)
PRS2 [cytosol]
(Saccharomyces cerevisiae)
prps1b [cytosol]
(Danio rerio)
prps1a [cytosol]
(Danio rerio)
Prps [cytosol]
(Drosophila melanogaster)
PRS5 [cytosol]
(Saccharomyces cerevisiae)
prsB [cytosol]
(Dictyostelium discoideum)
PRS4 [cytosol]
(Saccharomyces cerevisiae)
PRPS1 [cytosol]
(Bos taurus)
PRPS1 [cytosol]
(Caenorhabditis elegans)
PRPS1 [cytosol]
(Canis familiaris)
PRPS1 [cytosol]
(Plasmodium falciparum)
PRPS1 [cytosol]
(Schizosaccharomyces pombe)
PRPS1 [cytosol]
(Sus scrofa)
prsC [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_002755.1
,
NP_001191331.1
OpenTargets
ENSG00000147224
HPA
ENSG00000147224-PRPS1
GeneCards
P60891
Ensembl
ENST00000372435
,
ENSG00000147224
,
ENSP00000361512
ZINC target
P60891
PRO
P60891
Pharos - Targets
P60891
Orphanet
15153
GlyGen
P60891
HMDB Protein
HMDBP00628
PDB
4M0P
,
4LZO
,
3S5J
,
4LZN
,
2H08
,
2H07
,
4F8E
,
4M0U
,
3EFH
,
2H06
,
2HCR
,
4LYG
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q13569 TDG
3
polySUMO2,3-K330-TDG [nucleoplasm]
(R-HSA-4551628)
TDG [nucleoplasm]
(R-HSA-65812)
monoSUMO1-K330-TDG [nucleoplasm]
(R-HSA-4551718)
0.556
3
UniProt:Q86WV5 TEN1
1
TEN1 [nucleoplasm]
(R-HSA-9668823)
0.556
3
UniProt:O15534 PER1
4
p-S-PER1 [cytosol]
(R-HSA-400310)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.556
3
UniProt:Q99967 CITED2
1
CITED2 [nucleoplasm]
(R-HSA-6804489)
0.556
3
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.556
3
UniProt:O15287 FANCG
1
FANCG [nucleoplasm]
(R-HSA-419532)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:A1L190 SYCE3
1
SYCE3 [nucleoplasm]
(R-HSA-8867779)
0.556
3
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