Reactome | PRPS1 [cytosol]

PRPS1 [cytosol]

Stable Identifier

R-HSA-73483

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phosphoribosyl pyrophosphate synthetase 1, Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PPRibP) (PRS-I), Ribose-phosphate pyrophosphokinase I , Phosphoribosyl pyrophosphate synthetase I, PPRibP, PRS-I

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60891 PRPS1

Gene Names

PRPS1

Chain

initiator methionine:, chain:2-318

Reference Genes

BioGPS Gene:5631 PRPS1

COSMIC (genes):PRPS1 PRPS1

CTD Gene:5631 PRPS1

dbSNP Gene:5631 PRPS1

ENSEMBL:ENSG00000147224 PRPS1

ENSEMBL_homo_sapiens_GENE:ENSG00000147224.13 PRPS1

HGNC:9462 PRPS1

KEGG Gene (Homo sapiens):5631 PRPS1

Monarch:5631 PRPS1

NCBI Gene:5631 PRPS1

OMIM:311850 PRPS1

UCSC:P60891 PRPS1

Reference Transcript

Other Identifiers

11717084_a_at

11717085_a_at

17106031

208447_PM_s_at

208447_s_at

209440_PM_at

209440_at

3189073

3189077

36489_at

36490_s_at

3986515

3986516

3986517

3986518

3986521

3986524

3986525

3986527

3986528

3986529

5631

8169240

A_23_P95764

D00860_at

GE57039

GE57982

GO:0000166

GO:0000287

GO:0002189

GO:0003824

GO:0004749

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006015

GO:0006144

GO:0006164

GO:0006221

GO:0006796

GO:0007399

GO:0009156

GO:0009165

GO:0016301

GO:0016310

GO:0016740

GO:0034418

GO:0042802

GO:0042803

GO:0044249

GO:0046101

GO:0046872

GO:0048856

GO:0055086

GO:0090407

GO:1901135

HMNXSV003040263

ILMN_1667050

PH_hs_0000008

TC0X000526.hg

X15331_s_at

g12804406_3p_at

g4506126_3p_a_at

Participates

as a component of

PRPS1 dimer [cytosol] (Homo sapiens)

Inferred To

prps1 [cytosol] (Xenopus tropicalis)

prps1b [cytosol] (Danio rerio)

PRPS1 [cytosol] (Bos taurus)

PRPS1 [cytosol] (Canis familiaris)

PRPS1 [cytosol] (Dictyostelium discoideum)

PRPS1 [cytosol] (Gallus gallus)

PRPS1 [cytosol] (Mus musculus)

PRPS1 [cytosol] (Plasmodium falciparum)

PRPS1 [cytosol] (Rattus norvegicus)

PRPS1 [cytosol] (Saccharomyces cerevisiae)

PRPS1 [cytosol] (Schizosaccharomyces pombe)

PRPS1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001191331.1, NP_002755.1

OpenTargets

ENSG00000147224

GeneCards

P60891

HPA

ENSG00000147224-PRPS1

ZINC target

P60891

Ensembl

ENSP00000361512, ENSG00000147224, ENST00000372435

PRO

P60891

Pharos - Targets

P60891

Orphanet

15153

HMDB Protein

HMDBP00628

PDB

8DBF, 8DBM, 8DBE, 8DBL, 4M0U, 4LZO, 4F8E, 8DBH, 4M0P, 8DBG, 8DBO, 8DBN, 4LZN, 3S5J, 2HCR, 2H06, 8DBI, 3EFH, 4LYG, 2H08, 8DBD, 8DBC, 8DBK, 2H07, 8DBJ

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q13569 TDG	3	polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) TDG [nucleoplasm] (R-HSA-65812)	0.556	3
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:A1L190 SYCE3	1	SYCE3 [nucleoplasm] (R-HSA-8867779)	0.556	3
UniProt:Q99967 CITED2	1	CITED2 [nucleoplasm] (R-HSA-6804489)	0.556	3
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.556	3
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.527	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2

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