Reactome | PRPS1 [cytosol]

PRPS1 [cytosol]

Stable Identifier

R-HSA-73483

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phosphoribosyl pyrophosphate synthetase 1, Ribose-phosphate pyrophosphokinase I (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase I) (PPRibP) (PRS-I), Ribose-phosphate pyrophosphokinase I , Phosphoribosyl pyrophosphate synthetase I, PPRibP, PRS-I

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60891 PRPS1

Gene Names

PRPS1

Chain

initiator methionine:1, chain:2-318

Reference Genes

BioGPS Gene:5631 PRPS1

COSMIC (genes):PRPS1 PRPS1

CTD Gene:5631 PRPS1

dbSNP Gene:5631 PRPS1

ENSEMBL:ENSG00000147224 PRPS1

HGNC:9462 PRPS1

KEGG Gene (Homo sapiens):5631 PRPS1

Monarch:5631 PRPS1

NCBI Gene:5631 PRPS1

OMIM:311850 PRPS1

UCSC:P60891 PRPS1

Reference Transcript

Other Identifiers

0006040717

11717084_a_at

11717085_a_at

17106031

208447_s_at

209440_at

3189073

3189077

36489_at

36490_s_at

3986515

3986516

3986517

3986518

3986521

3986524

3986525

3986527

3986528

3986529

5631

8169240

A_23_P95764

D00860_at

GE57039

GE57982

GO:0000166

GO:0000287

GO:0002189

GO:0003674

GO:0004749

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006015

GO:0006144

GO:0006164

GO:0006221

GO:0007399

GO:0008150

GO:0009058

GO:0009116

GO:0009156

GO:0009165

GO:0016301

GO:0016310

GO:0016740

GO:0032991

GO:0034418

GO:0034641

GO:0042802

GO:0042803

GO:0043167

GO:0044249

GO:0044281

GO:0046101

GO:0046872

GO:0048856

HMNXSV003040263

ILMN_1667050

PH_hs_0000008

TC0X000526.hg

X15331_s_at

g12804406_3p_at

g4506126_3p_a_at

Participates

as a component of

PRPS1 dimer [cytosol] (Homo sapiens)

Inferred To

PRS3 [cytosol] (Saccharomyces cerevisiae)

PRPS1L1 [cytosol] (Gallus gallus)

Homologues of PRPS1 [cytosol] (Danio rerio)

Homologues of PRPS1 [cytosol] (Dictyostelium discoideum)

Homologues of PRPS1 [cytosol] (Plasmodium falciparum)

Homologues of PRPS1 [cytosol] (Saccharomyces cerevisiae)

Homologues of PRPS1 [cytosol] (Schizosaccharomyces pombe)

Prps1 [cytosol] (Mus musculus)

Prps1 [cytosol] (Rattus norvegicus)

prsA [cytosol] (Dictyostelium discoideum)

PRS1 [cytosol] (Saccharomyces cerevisiae)

PRS2 [cytosol] (Saccharomyces cerevisiae)

prps1b [cytosol] (Danio rerio)

prps1a [cytosol] (Danio rerio)

Prps [cytosol] (Drosophila melanogaster)

PRS5 [cytosol] (Saccharomyces cerevisiae)

prsB [cytosol] (Dictyostelium discoideum)

PRS4 [cytosol] (Saccharomyces cerevisiae)

PRPS1 [cytosol] (Bos taurus)

PRPS1 [cytosol] (Caenorhabditis elegans)

PRPS1 [cytosol] (Canis familiaris)

PRPS1 [cytosol] (Plasmodium falciparum)

PRPS1 [cytosol] (Schizosaccharomyces pombe)

PRPS1 [cytosol] (Sus scrofa)

prsC [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002755.1, NP_001191331.1

Target Pathogen

5b354852be737e166372e9f0

OpenTargets

ENSG00000147224

HPA

ENSG00000147224-PRPS1

GeneCards

P60891

ZINC target

P60891

Ensembl

ENSP00000361512, ENST00000372435, ENSG00000147224

PRO

P60891

Orphanet

15153

HMDB Protein

HMDBP00628

PDB

4LYG, 3EFH, 2H06, 4M0U, 2H08, 4M0P, 4LZO, 2HCR, 3S5J, 4F8E, 4LZN, 2H07

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:A1L190 SYCE3	1	SYCE3 [nucleoplasm] (R-HSA-8867779)	0.556	3
UniProt:Q99967 CITED2	1	CITED2 [nucleoplasm] (R-HSA-6804489)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [nucleoplasm] (R-HSA-3325590) p-S-PER1 [cytosol] (R-HSA-400310) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q13569 TDG	3	TDG [nucleoplasm] (R-HSA-65812) SUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) SUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:O15287 FANCG	1	FANCG [nucleoplasm] (R-HSA-419532)	0.556	3

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