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TYMS [cytosol]
Stable Identifier
R-HSA-73518
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Thymidylate synthase , TS, TSase
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
TYMS gene expression (Homo sapiens)
TYMS [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Homo sapiens)
TS dimer [cytosol] (Homo sapiens)
TYMS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04818 TYMS
Gene Names
TYMS, TS, OK/SW-cl.29
Chain
initiator methionine:, chain:2-313
Reference Genes
BioGPS Gene:7298 TYMS
COSMIC (genes):TYMS TYMS
CTD Gene:7298 TYMS
dbSNP Gene:7298 TYMS
ENSEMBL:ENSG00000176890 TYMS
ENSEMBL_homo_sapiens_GENE:ENSG00000176890.16 TYMS
HGNC:12441 TYMS
KEGG Gene (Homo sapiens):7298 TYMS
Monarch:7298 TYMS
NCBI Gene:7298 TYMS
OMIM:188350 TYMS
UCSC:P04818 TYMS
Reference Transcript
RefSeq:NM_001071.2 TYMS
Other Identifiers
11718058_a_at
11751805_a_at
1505_at
1554696_PM_s_at
1554696_s_at
16850477
202589_PM_at
202589_at
3775843
3775844
3775845
3775846
3775847
3775853
3775855
3775856
3775861
3775862
3775864
3775865
3775866
3775867
3775868
37899_at
7298
8019842
A_23_P50096
D00596_at
GE59639
GO:0000900
GO:0003723
GO:0003729
GO:0003824
GO:0004799
GO:0005542
GO:0005634
GO:0005737
GO:0005739
GO:0005743
GO:0005759
GO:0005829
GO:0006206
GO:0006231
GO:0006235
GO:0006417
GO:0006575
GO:0007623
GO:0008168
GO:0009165
GO:0009410
GO:0009636
GO:0014070
GO:0016020
GO:0016740
GO:0016741
GO:0017148
GO:0019860
GO:0030154
GO:0032259
GO:0032570
GO:0033189
GO:0034097
GO:0035999
GO:0042803
GO:0043226
GO:0045182
GO:0045471
GO:0046653
GO:0046683
GO:0048589
GO:0048856
GO:0051216
GO:0051384
GO:0051593
GO:0055086
GO:0060574
GO:0071897
GO:0097421
GO:1901135
GO:1901363
GO:1990825
HMNXSV003037502
Hs2.432651.1.S1_3p_s_at
ILMN_1806040
PH_hs_0022201
TC18000006.hg
g4507750_3p_at
Participates
as an output of
TYMS gene expression (Homo sapiens)
as a component of
TS dimer [cytosol] (Homo sapiens)
Inferred To
TYMS [cytosol]
(Bos taurus)
TYMS [cytosol]
(Canis familiaris)
TYMS [cytosol]
(Drosophila melanogaster)
TYMS [cytosol]
(Mus musculus)
TYMS [cytosol]
(Plasmodium falciparum)
TYMS [cytosol]
(Rattus norvegicus)
TYMS [cytosol]
(Saccharomyces cerevisiae)
TYMS [cytosol]
(Schizosaccharomyces pombe)
TYMS [cytosol]
(Sus scrofa)
zgc:56465 [cytosol]
(Danio rerio)
tyms [cytosol]
(Xenopus tropicalis)
tyms-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001062.1
ZINC - World Drugs
TYSY_HUMAN
Guide to Pharmacology - Targets
2642
OpenTargets
ENSG00000176890
ZINC - FDA approved
TYSY_HUMAN
ZINC - Substances
TYSY_HUMAN
ZINC target
P04818
ZINC - Biogenic
TYSY_HUMAN
PRO
P04818
PDB
5X5Q
,
3GH0
,
6OJU
,
1I00
,
3EAW
,
5X4W
,
5HS3
,
6PF4
,
2ONB
,
6PF5
,
3GH2
,
3EHI
,
4FGT
,
5X67
,
6QXH
,
4G6W
,
3EJL
,
5X69
,
4UP1
,
5X66
,
1HVY
,
3H9K
,
1HW3
,
4O1U
,
3HB8
,
3GG5
,
4O1X
,
5X5A
,
4GD7
,
3N5E
,
3EBU
,
1HW4
,
4E28
,
2RDA
,
3EGY
,
3N5G
,
5X5D
,
3OB7
,
1YPV
,
4JEF
,
6R2E
,
4G2O
,
6QYQ
,
4H1I
,
1JU6
,
3EDW
,
5X4X
,
2RD8
,
5X4Y
,
4KPW
,
6PF6
,
4GYH
,
6OJV
,
6QXG
,
3ED7
,
3EF9
,
1JUJ
,
5WRN
,
6ZXO
,
6PF3
,
1HZW
ZINC - Investigational
TYSY_HUMAN
ZINC - Metabolites
TYSY_HUMAN
HPA
ENSG00000176890-TYMS
GeneCards
P04818
Ensembl
ENSG00000176890
,
ENST00000323224
,
ENST00000323274
,
ENSP00000315644
,
ENSP00000314902
,
ENSP00000314727
,
ENST00000323250
Pharos - Targets
P04818
ZINC - Predictions - Purchasable
TYSY_HUMAN
Orphanet
19453
HMDB Protein
HMDBP04363
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
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