dCMP + H2O => dUMP + NH4+

Stable Identifier
R-HSA-73596
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
deamination of dCMP to form dUMP
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dCMP + H2O => dUMP + NH4+
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Cytosolic deoxycytidylate deaminase (DCTD) catalyzes the hydrolysis of dCMP (2'-deoxyuridine 5'-monophosphate) to yield dUMP (2'-deoxyuridine 5'-monophosphate) and ammonia. The active enzyme is a homohexamer (Maley et al. 1993; Weiner et al. 1993; unpublished crystallography data - PDB 2W4L).

Literature References
PubMed ID Title Journal Year
7685356 Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli

Weiner, KX, Weiner, RS, Maley, F, Maley, GF

J Biol Chem 1993
8448179 Properties of an affinity-column-purified human deoxycytidylate deaminase

Maley, GF, Lobo, AP, Maley, F

Biochim Biophys Acta 1993
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Catalyst Activity

dCMP deaminase activity of DCTD hexamer [cytosol]

Physical Entity
DCTD hexamer [cytosol] (Homo sapiens)
Activity
dCMP deaminase activity (GO:0004132)
Orthologous Events
dCMP + H2O => dUMP + NH4+ (Bos taurus)
dCMP + H2O => dUMP + NH4+ (Canis familiaris)
dCMP + H2O => dUMP + NH4+ (Danio rerio)
dCMP + H2O => dUMP + NH4+ (Gallus gallus)
dCMP + H2O => dUMP + NH4+ (Mus musculus)
dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)
dCMP + H2O => dUMP + NH4+ (Sus scrofa)
Cross References
Rhea
Created
Jassal, B  (2003-06-17)
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