dCMP + H2O => dUMP + NH4+

Stable Identifier
R-HSA-73596
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
deamination of dCMP to form dUMP
ReviewStatus
5/5
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dCMP + H2O => dUMP + NH4+
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Cytosolic deoxycytidylate deaminase (DCTD) catalyzes the hydrolysis of dCMP (2'-deoxyuridine 5'-monophosphate) to yield dUMP (2'-deoxyuridine 5'-monophosphate) and ammonia. The active enzyme is a homohexamer (Maley et al. 1993; Weiner et al. 1993; unpublished crystallography data - PDB 2W4L).
Literature References
PubMed ID Title Journal Year
8448179 Properties of an affinity-column-purified human deoxycytidylate deaminase

Maley, GF, Lobo, AP, Maley, F

Biochim Biophys Acta 1993
7685356 Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli

Maley, GF, Weiner, RS, Weiner, KX, Maley, F

J Biol Chem 1993
Participants
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Output
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as an event of
Catalyst Activity

dCMP deaminase activity of DCTD hexamer [cytosol]

Physical Entity
DCTD hexamer [cytosol] (Homo sapiens)
Activity
dCMP deaminase activity (GO:0004132)
Orthologous Events
dCMP + H2O => dUMP + NH4+ (Bos taurus)
dCMP + H2O => dUMP + NH4+ (Canis familiaris)
dCMP + H2O => dUMP + NH4+ (Danio rerio)
dCMP + H2O => dUMP + NH4+ (Gallus gallus)
dCMP + H2O => dUMP + NH4+ (Mus musculus)
dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)
dCMP + H2O => dUMP + NH4+ (Sus scrofa)
dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-06-17)
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