Reactome | cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]

cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]

Stable Identifier

R-HSA-73599

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]

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Cytosolic uridine-cytidine kinase 1 (UCK1) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Unpublished crystallographic data show the enzyme to be a tetramer (PDB - 2JEO).

Literature References

PubMed ID	Title	Journal	Year
195585	Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma Greenberg, N, Schumm, DE, Webb, TE	Biochem J	1977
11306702	Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases Van Rompay, AR, Norda, A, Linden, K, Johansson, M, Karlsson, A	Mol Pharmacol	2001