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RRM2 [cytosol]
Stable Identifier
R-HSA-73639
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ribonucleotide reductase M2 polypeptide, Ribonucleoside-diphosphate reductase M2 chain (EC 1.17.4.1) (Ribonucleotide reductase small chain), Ribonucleoside-diphosphate reductase M2 chain , Ribonucleotide reductase small chain
Locations in the PathwayBrowser for interactor UniProt:O00560%20SDCBP
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
RRM2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
RRM2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31350 RRM2
Gene Names
RRM2, RR2
Chain
chain:1-389
Reference Genes
BioGPS Gene:6241 RRM2
COSMIC (genes):RRM2 RRM2
CTD Gene:6241 RRM2
dbSNP Gene:6241 RRM2
ENSEMBL:ENSG00000171848 RRM2
ENSEMBL_homo_sapiens_GENE:ENSG00000171848.16 RRM2
HGNC:10452 RRM2
KEGG Gene (Homo sapiens):6241 RRM2
Monarch:6241 RRM2
NCBI Gene:6241 RRM2
OMIM:180390 RRM2
UCSC:P31350 RRM2
Reference Transcript
RefSeq:NM_001165931.1 RRM2
RefSeq:NM_001034.3 RRM2
Other Identifiers
11754360_a_at
11758219_x_at
16877019
201890_PM_at
201890_at
209773_PM_s_at
209773_s_at
2440825
2469251
2469253
2469254
2469255
2469257
2469258
2469260
2469263
2469267
2469269
2469273
2469274
2469275
2469276
2469277
2469278
2469279
2469280
2469281
36922_at
4006364
4006368
6241
77842_at
8040223
A_14_P120837
A_14_P131994
A_24_P225616
A_24_P234196
GE576460
GE59846
GO:0000278
GO:0001824
GO:0003824
GO:0004748
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005971
GO:0006260
GO:0008199
GO:0009185
GO:0009262
GO:0009263
GO:0009265
GO:0016491
GO:0042802
GO:0042803
GO:0043226
GO:0046872
GO:0048856
GO:0051290
GO:0055086
GO:0065003
GO:1900087
GO:1901135
HMNXSV003027599
Hs.75319.0.S3_3p_at
ILMN_1678669
PH_hs_0023142
TC02000057.hg
X59618_at
g12804874_3p_a_at
Participates
as an output of
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
as a component of
RRM2 dimer [cytosol] (Homo sapiens)
Inferred To
rrm2.2 [cytosol]
(Xenopus tropicalis)
RRM2 [cytosol]
(Bos taurus)
RRM2 [cytosol]
(Caenorhabditis elegans)
RRM2 [cytosol]
(Canis familiaris)
RRM2 [cytosol]
(Danio rerio)
RRM2 [cytosol]
(Dictyostelium discoideum)
RRM2 [cytosol]
(Drosophila melanogaster)
RRM2 [cytosol]
(Mus musculus)
RRM2 [cytosol]
(Plasmodium falciparum)
RRM2 [cytosol]
(Rattus norvegicus)
RRM2 [cytosol]
(Saccharomyces cerevisiae)
RRM2 [cytosol]
(Schizosaccharomyces pombe)
RRM2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001159403.1
,
NP_001025.1
Guide to Pharmacology - Targets
2631
OpenTargets
ENSG00000171848
ZINC - Substances
RIR2_HUMAN
ZINC target
P31350
PRO
P31350
PDB
3VPN
,
3VPO
,
3OLJ
,
2UW2
,
3VPM
GeneCards
P31350
HPA
ENSG00000171848-RRM2
Ensembl
ENSP00000302955
,
ENST00000304567
,
ENSG00000171848
,
ENST00000360566
,
ENST00000641198
,
ENSP00000493399
,
ENSP00000353770
Pharos - Targets
P31350
ZINC - Predictions - Purchasable
RIR2_HUMAN
HMDB Protein
HMDBP00111
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23921 RRM1
1
RRM1 [cytosol]
(R-HSA-73638)
0.806
6
UniProt:P41002 CCNF
1
CCNF [cytosol]
(R-HSA-8862602)
0.628
12
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q9UM11 FZR1
4
FZR1 [cytosol]
(R-HSA-174249)
FZR1 [nucleoplasm]
(R-HSA-174099)
p-FZR1 [nucleoplasm]
(R-HSA-174257)
p-FZR1 [cytosol]
(R-HSA-174193)
0.499
2
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