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2xHC-TXN [cytosol]
Stable Identifier
R-HSA-73668
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Thioredoxin, oxidized, Thioredoxin, ATL-derived factor, ADF, Surface associated sulphydryl protein, SASP
Locations in the PathwayBrowser for interactor UniProt:P01023 A2M
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
PRDX5 reduces peroxynitrite to nitrite using TXN (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
ROS oxidize thioredoxin (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
TXNIP is released from oxidized thioredoxin (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
ROS oxidize thioredoxin (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
TXNIP is released from oxidized thioredoxin (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Protein repair (Homo sapiens)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Homo sapiens)
2xHC-TXN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10599 TXN
Gene Names
TXN, TRDX, TRX, TRX1
Chain
initiator methionine:, chain:2-105
Reference Genes
BioGPS Gene:7295 TXN
COSMIC (genes):TXN TXN
CTD Gene:7295 TXN
dbSNP Gene:7295 TXN
ENSEMBL:ENSG00000136810 TXN
ENSEMBL_homo_sapiens_GENE:ENSG00000136810.13 TXN
HGNC:12435 TXN
KEGG Gene (Homo sapiens):7295 TXN
Monarch:7295 TXN
NCBI Gene:7295 TXN
OMIM:187700 TXN
UCSC:P10599 TXN
Reference Transcript
RefSeq:NM_001244938.1 TXN
RefSeq:NM_003329.3 TXN
Other Identifiers
11715469_s_at
11715470_x_at
11750538_x_at
11753775_x_at
11753804_x_at
17097052
208864_PM_s_at
208864_s_at
3220157
3220158
3220159
3220160
3220162
3220166
3220168
3220174
3220175
36992_at
7295
8163185
A_23_P60248
GE81265
GO:0000122
GO:0003723
GO:0003824
GO:0004791
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006886
GO:0006913
GO:0009314
GO:0015035
GO:0016209
GO:0016491
GO:0023052
GO:0032148
GO:0033138
GO:0036211
GO:0042803
GO:0043226
GO:0043388
GO:0045454
GO:0046826
GO:0047134
GO:0051897
GO:0061692
GO:0070062
GO:0071731
GO:0098754
GO:0140096
GO:2000170
HMNXSV003001941
HMNXSV003052323
ILMN_1680314
ILMN_2038776
PH_hs_0030018
PH_hs_0040358
TC09001473.hg
X77584_at
g11345419_3p_at
g11345419_3p_s_at
Participates
as an output of
MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Homo sapiens)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Homo sapiens)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
PRDX5 reduces peroxynitrite to nitrite using TXN (Homo sapiens)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
ROS oxidize thioredoxin (Homo sapiens)
TXNIP is released from oxidized thioredoxin (Homo sapiens)
ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)
as an input of
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
as a component of
Oxidized thioredoxin:TXNIP [cytosol] (Homo sapiens)
Other forms of this molecule
2xHC-TXN [nucleoplasm]
TXN [nucleoplasm]
TXN [cytosol]
Inferred To
2xHC-TXN [cytosol]
(Plasmodium falciparum)
trx1 [cytosol]
(Schizosaccharomyces pombe)
txna [cytosol]
(Danio rerio)
trx2 [cytosol]
(Schizosaccharomyces pombe)
trxC [cytosol]
(Dictyostelium discoideum)
txnb [cytosol]
(Danio rerio)
TXN [cytosol]
(Bos taurus)
TXN [cytosol]
(Canis familiaris)
TXN [cytosol]
(Gallus gallus)
TXN [cytosol]
(Sus scrofa)
Trx2 [cytosol]
(Drosophila melanogaster)
trxD [cytosol]
(Dictyostelium discoideum)
trx-1 [cytosol]
(Caenorhabditis elegans)
TRX1 [cytosol]
(Plasmodium falciparum)
TRX1 [cytosol]
(Saccharomyces cerevisiae)
TRX2 [cytosol]
(Saccharomyces cerevisiae)
Txn [cytosol]
(Mus musculus)
Txn [cytosol]
(Rattus norvegicus)
TRX3 [cytosol]
(Plasmodium falciparum)
TRX3 [cytosol]
(Saccharomyces cerevisiae)
Homologues of 2xHC-TXN [cytosol]
(Danio rerio)
Homologues of 2xHC-TXN [cytosol]
(Dictyostelium discoideum)
Homologues of 2xHC-TXN [cytosol]
(Plasmodium falciparum)
Homologues of 2xHC-TXN [cytosol]
(Saccharomyces cerevisiae)
Homologues of 2xHC-TXN [cytosol]
(Schizosaccharomyces pombe)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 32 and 35
Coordinate
32
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_003320.2
,
NP_001231867.1
OpenTargets
ENSG00000136810
ZINC - Substances
THIO_HUMAN
ZINC target
P10599
ZINC - Biogenic
THIO_HUMAN
PRO
P10599
PDB
5DQY
,
4TRX
,
3M9K
,
1MDI
,
2IIY
,
1MDK
,
1AUC
,
4POM
,
1MDJ
,
4PUF
,
4POL
,
1TRS
,
2HSH
,
1ERT
,
4OO4
,
3QFA
,
1CQG
,
3QFB
,
1TRU
,
1AIU
,
1ERU
,
2IFQ
,
1CQH
,
1TRV
,
1ERV
,
4OO5
,
4LL1
,
3TRX
,
1ERW
,
3E3E
,
1M7T
,
3KD0
,
1TRW
,
4LL4
,
3M9J
,
4POK
,
2HXK
ZINC - Investigational
THIO_HUMAN
HPA
ENSG00000136810-TXN
GeneCards
P10599
Ensembl
ENSP00000363641
,
ENSP00000363639
,
ENST00000374515
,
ENSG00000136810
,
ENST00000374517
Pharos - Targets
P10599
ZINC - Predictions - Purchasable
THIO_HUMAN
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.785
5
UniProt:Q9H3M7 TXNIP
2
TXNIP [cytosol]
(R-HSA-1250246)
TXNIP [nucleoplasm]
(R-HSA-9617747)
0.743
8
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.736
9
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.677
4
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.675
4
UniProt:P42574 CASP3
5
CASP3(1-277) [cytosol]
(R-HSA-57021)
CASP3(29-175) [nucleoplasm]
(R-HSA-211194)
CASP3(176-277) [nucleoplasm]
(R-HSA-211203)
CASP3(29-175) [cytosol]
(R-HSA-141644)
CASP3(176-277) [cytosol]
(R-HSA-141646)
0.672
6
UniProt:D0ZRB2 SLRP
0.633
7
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.602
4
UniProt:O95831 AIFM1
0.569
3
UniProt:P32119 PRDX2
2
p-T89-PRDX2 [cytosol]
(R-HSA-8868574)
PRDX2 [cytosol]
(R-HSA-3341292)
0.564
2
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:P51608 MECP2
0.556
3
UniProt:P50570-2 DNM2
0.556
3
UniProt:Q14114-3 Q141143
0.556
3
UniProt:Q9BXU3 TX13A
0.556
3
UniProt:Q96D03 DDT4L
0.556
5
UniProt:Q9Y605 MOFA1
0.556
3
UniProt:Q9NZD8 SPG21
0.556
6
UniProt:P01023 A2M
2
A2M [extracellular region]
(R-HSA-49291)
A2M [platelet alpha granule lumen]
(R-HSA-139834)
0.556
3
UniProt:P19883 FST
1
FST [extracellular region]
(R-HSA-2473211)
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:P37198 NUP62
2
NUP62 [cytosol]
(R-HSA-9634226)
NUP62 [nuclear envelope]
(R-HSA-157713)
0.556
3
UniProt:P23560-2 BDNF
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:Q9GZT8 NIF3L
0.556
3
UniProt:X5D778 X5D778
0.556
6
UniProt:Q9UJW9 SRTD3
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.556
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q5JTV8 TOR1AIP1
1
TOR1AIP1 [cytosol]
(R-HSA-9715083)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
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