Acetylation of SL1

Stable Identifier
R-HSA-73736
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Acetylation of the TAFI63 subunit of SL1 by PCAF stimulates the association of TAFI63 with DNA and stimulates pol I transcription in vitro. Conversely, deacetylation by the NAD+-dependent deacetylase Sir2 represses pol I transcription.
Literature References
PubMed ID Title Journal Year
11250901 Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.

Nadaud, S, Voit, R, Grummt, I, Muth, V

EMBO J 2001
Participants
Participates
Catalyst Activity

acetyltransferase activity of PCAF [nucleoplasm]

Inferred From
Authored
Created
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