Reactome | RNA Polymerase I Promoter Escape

RNA Polymerase I Promoter Escape

Stable Identifier

R-HSA-73772

Type

Pathway

Species

Homo sapiens

Compartment

nucleolus

ReviewStatus

5/5

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As the active RNA Polymerase I complex leaves the promoter Rrn3 dissociates from the complex. RNA polymerase I Promoter Clearance is complete and Chain Elongation begins (Milkereit and Tschochner, 1998). The assembly of the initiation complex on the promoter and the transition from a closed to an open complex is then followed by promoter clearance and transcription elongation by RNA Pol I. Unlike the RNA polymerase II system, RNA polymerase I transcription does not require a form of energy such as ATP for initiation and elongation. Regulatory mechanisms operating at both the level of transcription initiation and elongation probably concurrently to adjust the level of rRNA synthesis to the need of the cell.

Literature References

PubMed ID	Title	Journal	Year
9649439	A specialized form of RNA polymerase I, essential for initiation and growth-dependent regulation of rRNA synthesis, is disrupted during transcription Tschochner, H, Milkereit, P	EMBO J.	1998
11032814	The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3 Carles, C, Sentenac, A, Schultz, P, Riva, M, Tschochner, H, Peyroche, G, Bischler, N, Milkereit, P	EMBO J.	2000