Reactome | AICAR + 10-Formyl-THF => FAICAR + THF

AICAR + 10-Formyl-THF => FAICAR + THF

Stable Identifier

R-HSA-73798

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate

ReviewStatus

5/5

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The irreversible transfer of a formyl group to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR), to yield 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR), is catalyzed by the phosphoribosylaminoimidazolecarboxamide formyltransferase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18388293	Reversible compartmentalization of de novo purine biosynthetic complexes in living cells Benkovic, SJ, Sheets, ED, Kumar, R, An, S	Science	2008
11096114	Human 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity Beardsley, GP, Vergis, JM, Bulock, KG, Fleming, KG	J Biol Chem	2001
8567683	The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Beardsley, GP, Rayl, EA, Moroson, BA	J Biol Chem	1996