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RNA Polymerase I Transcription Termination
Stable Identifier
R-HSA-73863
Type
Pathway
Species
Homo sapiens
Compartment
nucleolus
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Transcription Termination (Homo sapiens)
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Termination of transcription by RNA polymerase I is a 4 step process. Initially TTF-1 binds the template rDNA. This complex pauses polymerase I allowing PTRF to interact with the quaternary complex releasing both pre-rRNA and Pol I from the template and TTF-1.
Literature References
PubMed ID
Title
Journal
Year
14969726
Mechanism of RNA polymerase I transcription
Comai, L
Adv. Protein Chem.
2004
Participants
Events
TTF-I binds to the Sal Box
(Homo sapiens)
Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box
(Homo sapiens)
PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box
(Homo sapiens)
Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box
(Homo sapiens)
Participates
as an event of
RNA Polymerase I Transcription (Homo sapiens)
Event Information
Go Biological Process
termination of RNA polymerase I transcription (0006363)
Orthologous Events
RNA Polymerase I Transcription Termination (Bos taurus)
RNA Polymerase I Transcription Termination (Canis familiaris)
RNA Polymerase I Transcription Termination (Gallus gallus)
RNA Polymerase I Transcription Termination (Mus musculus)
RNA Polymerase I Transcription Termination (Rattus norvegicus)
RNA Polymerase I Transcription Termination (Sus scrofa)
RNA Polymerase I Transcription Termination (Xenopus tropicalis)
Authored
Comai, L (2003-07-03)
Created
Comai, L (2003-07-03)
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