Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the FASL:FAS Receptor Trimer:FADD:procaspase-8 receptor complex leading to the formation of the catalytically active form of procaspase-8.
Chang, DW, Peter, ME, Xing, Z, Yang, X, Capacio, VL
Cohen, GM, Butterworth, M, Harper, N, Cain, K, MacFarlane, M, Hughes, MA
Dixit, VM, Ashkenazi, A
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