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RNA Polymerase III Transcription Termination
Stable Identifier
R-HSA-73980
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase III Transcription (Homo sapiens)
RNA Polymerase III Transcription Termination (Homo sapiens)
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At the end of the cycle, the elongation complex (EC) must be destabilized to release its transcript and DNA. Analogous to initiation, cis-signals and protein factors are required to mediate EC destabilization and release of the transcript from the grip of the RNA polymerase (RNAP). RNAP III achieves efficient termination despite the apparent simplicity of its cis-acting DNA terminator element, a stretch of five or more T residues on the non-template (NT) strand, which directs termination within this site without need for additional cis-elements or trans-acting factors.
Literature References
PubMed ID
Title
Journal
Year
25959395
Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element
Maraia, RJ
,
Arimbasseri, AG
Mol. Cell
2015
Participants
Events
RNA Polymerase III Transcriptional Pause at Terminator Sequence
(Homo sapiens)
RNA Polymerase III Termination and release of transcribed RNA
(Homo sapiens)
Participates
as an event of
RNA Polymerase III Transcription (Homo sapiens)
Event Information
Go Biological Process
termination of RNA polymerase III transcription (0006386)
Authored
Geiduschek, EP (2004-02-27)
Kassavetis, GA (2004-02-27)
Created
Geiduschek, EP (2004-02-27)
Kassavetis, GA (2004-02-27)
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