RIP2-induced ubiquitination of NEMO and consequent NFkappaB activation can be reversed in a dose-responsive manner by the deubiquitinase CYLD, suggesting that CYLD negatively regulates RIP2-induced NEMO ubiquitinylation.
Cantarella, G, Wallach, D, Courtois, G, Chable-Bessia, C, Israel, A, Kovalenko, A
Asara, JM, Cantley, LC, Wilkins, A, Abbott, DW
Lys63-specific deubiquitinase activity of CYLD [cytosol]
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