Reactome | SLC35B2,3 transport cytosolic PAPS to Golgi lumen

SLC35B2,3 transport cytosolic PAPS to Golgi lumen

Stable Identifier

R-HSA-741449

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen, cytosol

ReviewStatus

5/5

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SLC35B2,3 transport cytosolic PAPS to Golgi lumen

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The human gene SLC35B2 encodes the adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPST1) (Ozeran et al. 1996, Kamiyama et al. 2003). In human tissues, PAPST1 is highly expressed in the placenta and pancreas and present at lower levels in the colon and heart. The human gene SLC35B3 encodes a human PAPS transporter gene that is closely related to PAPST1. Called PAPST2, it is predominantly expressed in the colon (Kamiyama et al. 2006). Both proteins can transport PAPS from the cytosol to the Golgi lumen.

Literature References

PubMed ID	Title	Journal	Year
16492677	Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2 Irimura, T, Sasaki, N, Kannagi, R, Kamiyama, S, Goda, E, Narimatsu, H, Nishihara, S, Ui-Tei, K, Jigami, Y, Saigo, K	J Biol Chem	2006
12716889	Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter Watanabe, M, Suda, T, Ueda, R, Narimatsu, H, Goto, S, Saigo, K, Chiba, Y, Suzuki, M, Toyoda, H, Kamiyama, S, Okubo, R, Kikuchi, N, Nishihara, S, Jigami, Y	J Biol Chem	2003
8619989	Identification and partial purification of PAPS translocase Schwartz, NB, Ozeran, JD, Westley, J	Biochemistry	1996