HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP

Stable Identifier
R-HSA-74215
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)
ReviewStatus
5/5
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HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP
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Cytosolic hypoxanthine-guanine phosphoribosyltransferase (HPRT1) tetramer catalyzes the reactions of guanine or hypoxanthine with PRPP to form GMP ir IMP and pyrophosphate (Holden and Kelley 1978; Jolly et al. 1983).

Literature References
PubMed ID Title Journal Year
6300847 Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

Bohlen, P, Esty, AC, Jolly, DJ, Hunkapillar, T, Johnson, GG, Berg, P, Friedmann, T, Filpula, D, Shively, JE, Okayama, H

Proc Natl Acad Sci U S A 1983
Participants
Input
Output
Participates
as an event of
Catalyst Activity

purine phosphoribosyltransferase activity of HPRT1 tetramer [cytosol]

Physical Entity
HPRT1 tetramer [cytosol] (Homo sapiens)
Activity
purine phosphoribosyltransferase activity (GO:0106130)
Orthologous Events
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Bos taurus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Gallus gallus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Sus scrofa)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-07-17)
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