Reactome | HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP

HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP

Stable Identifier

R-HSA-74215

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)

ReviewStatus

5/5

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HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP

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Cytosolic hypoxanthine-guanine phosphoribosyltransferase (HPRT1) tetramer catalyzes the reactions of guanine or hypoxanthine with PRPP to form GMP ir IMP and pyrophosphate (Holden and Kelley 1978; Jolly et al. 1983).

Literature References

PubMed ID	Title	Journal	Year
6300847	Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase Bohlen, P, Esty, AC, Jolly, DJ, Hunkapillar, T, Johnson, GG, Berg, P, Friedmann, T, Filpula, D, Shively, JE, Okayama, H	Proc Natl Acad Sci U S A	1983