Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Purine salvage
Stable Identifier
R-HSA-74217
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide salvage (Homo sapiens)
Purine salvage (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
Nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis and interconversion. Under normal conditions, DNA turnover is limited and deoxyribonucleotide salvage operates at a correspondingly low level (Watts 1974).
Literature References
PubMed ID
Title
Journal
Year
4620886
Molecular variation in relation to purine metabolism
Watts, RW
J Clin Pathol Suppl (R Coll Pathol)
1974
Participants
Events
deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)
(Homo sapiens)
APRT catalyzes the conversion of adenine to AMP
(Homo sapiens)
AMP + H2O => IMP + NH4+ (AMPD)
(Homo sapiens)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP
(Homo sapiens)
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)
(Homo sapiens)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine
(Homo sapiens)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine
(Homo sapiens)
(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)
(Homo sapiens)
ADA catalyzes the deamination of (deoxy)adenosine
(Homo sapiens)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine
(Homo sapiens)
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine
(Homo sapiens)
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)
(Homo sapiens)
Participates
as an event of
Nucleotide salvage (Homo sapiens)
Event Information
Go Biological Process
purine-containing compound salvage (0043101)
Orthologous Events
Purine salvage (Bos taurus)
Purine salvage (Caenorhabditis elegans)
Purine salvage (Canis familiaris)
Purine salvage (Danio rerio)
Purine salvage (Dictyostelium discoideum)
Purine salvage (Drosophila melanogaster)
Purine salvage (Gallus gallus)
Purine salvage (Mus musculus)
Purine salvage (Plasmodium falciparum)
Purine salvage (Rattus norvegicus)
Purine salvage (Saccharomyces cerevisiae)
Purine salvage (Schizosaccharomyces pombe)
Purine salvage (Sus scrofa)
Purine salvage (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000015
Authored
Jassal, B (2003-07-17)
Created
Jassal, B (2003-07-17)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text