PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose

Stable Identifier
R-HSA-74242
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)
ReviewStatus
5/5
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Cytosolic purine nucleoside phosphorylase (PNP) trimer catalyzes the reversible reaction of inosine or deoxyinosine with orthophosphate to form hypoxanthine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). While PNP is active with either nucleotide in vitro, levels of deoxyinosine are normally low in vivo, limiting the extent of this reaction. PNP deficiency in vivo is associated with accumulation of inosine and deoxyinosine and leads to immunodeficiency (Williams et al. 1987).
Literature References
PubMed ID Title Journal Year
3029074 A human purine nucleoside phosphorylase deficiency caused by a single base change

Williams, SR, Gekeler, V, McIvor, RS, Martin, Jr, DW

J Biol Chem 1987
6771276 Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides

Hutton, JJ, Wiginton, DA, Coleman, MS

J Biol Chem 1980
2104852 Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution

Cook, WJ, Habash, J, Greenhough, TJ, Babu, YS, Carter, DC, Parks, Jr, RE, Rule, SA, Bugg, CE, Stoeckler, JD, Chen, SF, Ealick, SE, Helliwell, JR

J Biol Chem 1990
Participants
Participates
Catalyst Activity

purine-nucleoside phosphorylase activity of PNP trimer [cytosol]

Orthologous Events
Cross References
Rhea
Created
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