Reactome | PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose

PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose

Stable Identifier

R-HSA-74249

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)

ReviewStatus

5/5

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PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose

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Cytosolic purine nucleoside phosphorylase (PNP) trimer catalyzes the reversible reaction of guanosine or deoxyguanosine with orthophosphate to form guanine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). PNP deficiency in vivo is associated with accumulation of guanosine and deoxyguanosine and leads to immunodeficiency (Williams et al. 1987).

Literature References

PubMed ID	Title	Journal	Year
3029074	A human purine nucleoside phosphorylase deficiency caused by a single base change Williams, SR, Gekeler, V, McIvor, RS, Martin, Jr, DW	J Biol Chem	1987
6771276	Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides Wiginton, DA, Coleman, MS, Hutton, JJ	J Biol Chem	1980
2104852	Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution Ealick, SE, Rule, SA, Carter, DC, Greenhough, TJ, Babu, YS, Cook, WJ, Habash, J, Helliwell, JR, Stoeckler, JD, Parks, Jr, RE, Chen, SF, Bugg, CE	J Biol Chem	1990