Reactome | SLC35D2 exchanges UDP-GlcNAc for UMP

SLC35D2 exchanges UDP-GlcNAc for UMP

Stable Identifier

R-HSA-744231

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
  - Glycosaminoglycan metabolism (Homo sapiens)
    - Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
      - HS-GAG biosynthesis (Homo sapiens)
        
        SLC35D2 exchanges UDP-GlcNAc for UMP (Homo sapiens)
    - Keratan sulfate/keratin metabolism (Homo sapiens)
      - Keratan sulfate biosynthesis (Homo sapiens)
        
        SLC35D2 exchanges UDP-GlcNAc for UMP (Homo sapiens)

General

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The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the transport of nucleotide sugars including UDP-GlcNAc into the Golgi lumen in exchange for UMP (Suda et al. 2004, Ishida et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15607426	Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family Ishida, N, Kuba, T, Aoki, K, Miyatake, S, Kawakita, M, Sanai, Y	Genomics	2005
15082721	Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection Suda, T, Kamiyama, S, Suzuki, M, Kikuchi, N, Nakayama, K, Narimatsu, H, Jigami, Y, Aoki, T, Nishihara, S	J Biol Chem	2004