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SHC1 [cytosol]
Stable Identifier
R-HSA-74680
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHC1 p66, SHC, SHC transforming protein
Icon
Locations in the PathwayBrowser for interactor UniProt:Q07889 SOS1
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
XBP1(S) activates chaperone genes (Homo sapiens)
Expression of SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
SHC1 binds phosphorylated ERBB2 homodimer (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by ERBB2 KD Mutants (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Tie2 Signaling (Homo sapiens)
Interaction of Tie2 and Shc1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates RAS (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
SHC1 events in EGFR signaling (Homo sapiens)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
SHC1 events in ERBB2 signaling (Homo sapiens)
SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
SHC1 events in ERBB4 signaling (Homo sapiens)
SHC1 binds P-ERBB4 isoform dimers (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
Binding of SHC1 to insulin receptor (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
Signal attenuation (Homo sapiens)
De-phosphorylation of p-Y427-SHC1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29353 SHC1
Gene Names
SHC1, SHC, SHCA
Chain
chain:1-583
Reference Genes
BioGPS Gene:6464 SHC1
COSMIC (genes):SHC1 SHC1
CTD Gene:6464 SHC1
dbSNP Gene:6464 SHC1
ENSEMBL:ENSG00000160691 SHC1
ENSEMBL_homo_sapiens_GENE:ENSG00000160691.19 SHC1
HGNC:10840 SHC1
KEGG Gene (Homo sapiens):6464 SHC1
Monarch:6464 SHC1
NCBI Gene:6464 SHC1
OMIM:600560 SHC1
UCSC:P29353 SHC1
Reference Transcript
RefSeq:NM_183001.4 SHC1
RefSeq:NM_001130040.1 SHC1
RefSeq:NM_001130041.1 SHC1
RefSeq:NM_001202859.1 SHC1
RefSeq:NM_003029.4 SHC1
Other Identifiers
11727363_a_at
11727364_s_at
11732136_a_at
11758297_s_at
16693891
16693898
201469_PM_s_at
201469_s_at
214853_PM_s_at
214853_s_at
2436980
2436981
2436982
2436983
2436984
2436986
2436987
2436988
2436989
2436990
2436991
2436992
2436995
2436996
2436997
2436998
2436999
2437000
2437002
2437003
2437004
2437005
2437006
2437007
2437009
2437010
2437011
2437012
2437013
2437014
2437015
2437016
2437018
3759015
3759016
38118_at
6464
7920600
A_23_P200443
A_24_P68585
GE59385
GO:0001525
GO:0001784
GO:0005068
GO:0005154
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005543
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0007010
GO:0007155
GO:0007173
GO:0007507
GO:0008284
GO:0008286
GO:0008289
GO:0012501
GO:0016525
GO:0023052
GO:0030036
GO:0030971
GO:0035556
GO:0042127
GO:0042742
GO:0043066
GO:0043226
GO:0043410
GO:0045892
GO:0045893
GO:0046875
GO:0048009
GO:0048408
GO:0048856
GO:0060090
GO:0070161
GO:0070374
GO:0070435
GO:0071363
GO:0071864
GO:0090322
GO:0098542
GO:0098609
HMNXSV003029143
HMNXSV003056955
Hs.81972.0.A1_3p_a_at
Hs.81972.1.A1_3p_a_at
ILMN_1701967
ILMN_1721022
ILMN_1812570
PH_hs_0030190
TC01006381.hg
U73377_at
Participates
as a component of
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Homo sapiens)
SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Homo sapiens)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants:SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:SHC1 [plasma membrane] (Homo sapiens)
p-ERBB2 homodimer:SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
as an input of
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Homo sapiens)
SHC1 binds P-ERBB4 isoform dimers (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Homo sapiens)
SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)
Binding of SHC1 to insulin receptor (Homo sapiens)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
Interaction of Tie2 and Shc1 (Homo sapiens)
Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)
SHC1 binds phosphorylated ERBB2 homodimer (Homo sapiens)
Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)
Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)
as an output of
De-phosphorylation of p-Y427-SHC1 (Homo sapiens)
Expression of SHC1 (Homo sapiens)
as a member of
SHC [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y427-SHC1 [cytosol]
p-Y349,Y350-SHC1 [cytosol]
p-Y349,Y350,Y427-SHC1 [cytosol]
p-Y-SHC1 [cytosol]
Inferred To
Shc [cytosol]
(Drosophila melanogaster)
Shc1 [cytosol]
(Mus musculus)
Shc1 [cytosol]
(Rattus norvegicus)
SHC1 [cytosol]
(Bos taurus)
SHC1 [cytosol]
(Canis familiaris)
SHC1 [cytosol]
(Gallus gallus)
SHC1 [cytosol]
(Sus scrofa)
Ghost homologue of SHC1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of SHC1 [cytosol]
(Danio rerio)
Ghost homologue of SHC1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001123513.1
,
NP_003020.2
,
NP_892113.4
,
NP_001123512.1
,
NP_001189788.1
OpenTargets
ENSG00000160691
HPA
ENSG00000160691-SHC1
ZINC - Substances
SHC1_HUMAN
GeneCards
P29353
ZINC target
P29353
Ensembl
ENST00000368450
,
ENST00000448116
,
ENSP00000401303
,
ENST00000368445
,
ENST00000368453
,
ENSP00000357438
,
ENSP00000357430
,
ENSG00000160691
,
ENSP00000357435
PRO
P29353
Pharos - Targets
P29353
ZINC - Predictions - Purchasable
SHC1_HUMAN
PDB
1MIL
,
1SHC
,
1N3H
,
4XWX
,
6DM4
,
1OY2
,
5CZI
,
1QG1
,
4JMH
,
1TCE
,
2L1C
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.976
44
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.976
33
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.856
9
UniProt:P62994 Grb2
3
Grb2 [cytosol]
(R-RNO-55929)
Grb2 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-74686)
0.822
5
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.821
16
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.816
6
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.77
5
UniProt:P21860 ERBB3
0.762
7
UniProt:O95782 AP2A1
5
AP2A1 [endolysosome membrane]
(R-HSA-6784829)
AP2A1 [endocytic vesicle membrane]
(R-HSA-416641)
AP2A1 [plasma membrane]
(R-HSA-177494)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138449)
AP2A1 [cytosol]
(R-HSA-182143)
0.725
6
UniProt:O94973 AP2A2
6
AP2A2(1-939) [endolysosome membrane]
(R-HSA-6784819)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-HSA-6800414)
AP2A2(1-939) [secretory granule membrane]
(R-HSA-6800412)
AP2A2(1-939) [plasma membrane]
(R-HSA-177502)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138448)
AP2A2(1-939) [cytosol]
(R-HSA-182155)
0.643
4
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.643
5
UniProt:Q16832 DDR2
1
DDR2 [plasma membrane]
(R-HSA-211419)
0.632
3
UniProt:Q15303 ERBB4
0.609
6
UniProt:Q12774 ARHGEF5
1
ARHGEF5 [cytosol]
(R-HSA-8873909)
0.597
4
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.589
6
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.573
2
UniProt:Q9UM73 ALK
20
p-7Y ALK T1087I [plasma membrane]
(R-HSA-9723885)
p-7Y ALK R1061Q [plasma membrane]
(R-HSA-9723884)
p-7Y ALK L1196M [plasma membrane]
(R-HSA-9700464)
p-7Y ALK M1166R [plasma membrane]
(R-HSA-9700477)
p-Y ALK S1206C [plasma membrane]
(R-HSA-9715292)
p- 7Y ALK L1122V [plasma membrane]
(R-HSA-9715294)
p-7Y ALK E1384K [plasma membrane]
(R-HSA-9715285)
p-7Y ALK L1196Q [plasma membrane]
(R-HSA-9700476)
p-7Y ALK V1180L [plasma membrane]
(R-HSA-9715289)
p-7Y ALK G1201R [plasma membrane]
(R-HSA-9701860)
p-7Y ALK I1171T [plasma membrane]
(R-HSA-9700489)
p-7Y ALK R1275L [plasma membrane]
(R-HSA-9699800)
p-7Y ALK F1174C [plasma membrane]
(R-HSA-9699821)
p-7Y ALK F1174V [plasma membrane]
(R-HSA-9699921)
p-7Y ALK M1166N [plasma membrane]
(R-HSA-9723299)
p-7Y ALK M1166T [plasma membrane]
(R-HSA-9700486)
p-7Y ALK Y1239H [plasma membrane]
(R-HSA-9715290)
p-7Y ALK R1275* [plasma membrane]
(R-HSA-9699915)
p-7Y ALK I1171S [plasma membrane]
(R-HSA-9714063)
p-7Y ALK G1128S [plasma membrane]
(R-HSA-9700462)
0.569
3
UniProt:P35968 KDR
5
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.564
2
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.564
2
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.564
2
UniProt:Q13137 CACO2
0.553
3
UniProt:P16573
11
Ceacam1 [extracellular region]
(R-RNO-8941137-3)
Ceacam1 [plasma membrane]
(R-RNO-8940816-3)
Ceacam1 [extracellular region]
(R-RNO-8870747-3)
Ceacam1 [extracellular region]
(R-RNO-8870766-3)
Ceacam1 [extracellular region]
(R-RNO-8870757-3)
Ceacam1 [extracellular region]
(R-RNO-8870759-3)
Ceacam1 [plasma membrane]
(R-RNO-197706-3)
Ceacam1 [specific granule membrane]
(R-RNO-6806076-3)
Ceacam1 [specific granule membrane]
(R-RNO-6799528)
Ceacam1 [plasma membrane]
(R-RNO-197701)
Ceacam1 [tertiary granule membrane]
(R-RNO-6800953)
0.544
3
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.544
2
UniProt:Q9UQC2 GAB2
5
p-Y643-GAB2 [cytosol]
(R-HSA-9677149)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
p-Y-GAB2 [cytosol]
(R-HSA-912529)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
GAB2 [cytosol]
(R-HSA-508239)
0.544
2
UniProt:P26954
4
phospho-Csf2rb2 [plasma membrane]
(R-MMU-914092)
phospho-Csf2rb2 [plasma membrane]
(R-MMU-914170)
Csf2rb2 [plasma membrane]
(R-MMU-879960)
phospho-Csf2rb2 [plasma membrane]
(R-MMU-912312)
0.544
4
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
0.527
3
UniProt:Q05655 PRKCD
12
PRKCD(1-676) [nucleoplasm]
(R-HSA-450606)
PRKCD(330-676) [extracellular region]
(R-HSA-6806199)
PRKCD(1-329) [extracellular region]
(R-HSA-6806226)
PRKCD(1-329) [azurophil granule lumen]
(R-HSA-6799219)
PRKCD(330-676) [azurophil granule lumen]
(R-HSA-6799221)
p-T507-PRKCD [cytosol]
(R-HSA-5218746)
p-T507,S645,S664-PRKCD [cytosol]
(R-HSA-5218734)
active p-T507,S645,S664-PRKCD [plasma membrane]
(R-HSA-5607635)
p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
(R-HSA-198294)
PRKCD(330-676) [cytosol]
(R-HSA-212551)
PRKCD(1-329) [cytosol]
(R-HSA-212547)
PRKCD [cytosol]
(R-HSA-58200)
0.527
3
UniProt:Q9H706 GARE1
0.527
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.527
2
UniProt:P32927 CSF2RB
6
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
0.527
4
UniProt:Q8TF42 UBS3B
0.527
3
UniProt:Q38SD2 LRRK1
0.527
3
UniProt:Q93008 USP9X
1
USP9X [cytosol]
(R-HSA-870499)
0.527
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.519
6
UniProt:P03495 NS1
0.508
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.483
3
UniProt:Q02763 TEK
2
TEK [plasma membrane]
(R-HSA-197755)
p-5Y,S1119-TEK [plasma membrane]
(R-HSA-204772)
0.462
2
UniProt:Q08345-1 DDR1
0.462
4
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.462
2
UniProt:A9UF07 A9UF07
0.462
4
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