Reactome | Insulin receptor de-phosphorylation

Insulin receptor de-phosphorylation

Stable Identifier

R-HSA-74733

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

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Endosomal protein tyrosine phosphatases (PTPs) dephosphorylate the insulin receptor, which cannot rephosphorylate itself as insulin is removed leaving the receptor in its inactive conformation (Bevan et al. 1996; Drake & Posner 1998). The identity of these PTPs is not definitively established, but structural studies and studies of cell lines and gene-knockout mice indicate that PTPRF / LAR (Ahmed & Goldstein 1997) and PTPN1 / PTP1B (Li et al. 2005) are each capable of mediating this reaction.

The dephosphorylated receptor recycles to the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
8995282	Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells Ahmad, F, Goldstein, BJ	J Biol Chem	1997
16271887	Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase Depetris, RS, Hubbard, SR, Li, S, Barford, D, Chernoff, J	Structure	2005
9609117	Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action. Drake, PG, Posner, BI	Mol Cell Biochem	1999
18406720	Intracellular Signal Transduction: The Role of Endosomes Bevan, AP, Drake, PG, Bergeron, JJ, Posner, BI	Trends in Endocrinology and Metabolism	1996