Binding of SHC1 to insulin receptor

Stable Identifier
R-HSA-74740
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Binding of SHC1 to insulin receptor
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SHC1 interacts via its SH2 domain with the carboxyterminal phosphorylated tyrosines of the insulin receptor. As a result, SHC1 is tyrosine phosphorylated by the insulin receptor, later falling away from the receptor (Liang et al.1999, Sasaoka et al.1996).
Literature References
PubMed ID Title Journal Year
8702728 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner

Sasaoka, T, Ishihara, H, Sawa, T, Ishiki, M, Morioka, H, Imamura, T, Usui, I, Takata, Y, Kobayashi, M

J. Biol. Chem. 1996
10218944 Insulin receptor substrate-1 enhances growth hormone-induced proliferation

Liang, L, Zhou, T, Jiang, J, Pierce, JH, Gustafson, TA, Frank, SJ

Endocrinology 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
GRB10:INSR [plasma membrane] (Homo sapiens)
Active Unit
GRB10 [cytosol]
Orthologous Events
Binding of SHC1 to insulin receptor (Bos taurus)
Binding of SHC1 to insulin receptor (Canis familiaris)
Binding of SHC1 to insulin receptor (Gallus gallus)
Binding of SHC1 to insulin receptor (Mus musculus)
Binding of SHC1 to insulin receptor (Rattus norvegicus)
Binding of SHC1 to insulin receptor (Sus scrofa)
Created
Bevan, AP  (2003-07-31)
Cite Us!