Phosphorylation of SHC1

Stable Identifier
R-HSA-74742
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
ReviewStatus
5/5
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Phosphorylation of SHC1
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SHC1 is tyrosine phosphorylated at Tyr-427 by the insulin receptor, later falling away from the receptor. Phosphorylation of SHC1 allows the SH2 domain of GRB2 to bind it (Sasaoka et al. 2000).
Literature References
PubMed ID Title Journal Year
11075717 The functional significance of Shc in insulin signaling as a substrate of the insulin receptor

Sasaoka, T, Kobayashi, M

Endocr. J. 2000
8702728 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner

Imamura, T, Sawa, T, Sasaoka, T, Usui, I, Takata, Y, Ishihara, H, Kobayashi, M, Morioka, H, Ishiki, M

J. Biol. Chem. 1996
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as an event of
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane]

Physical Entity
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Homo sapiens)
Activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Orthologous Events
Phosphorylation of SHC1 (Bos taurus)
Phosphorylation of SHC1 (Canis familiaris)
Phosphorylation of SHC1 (Gallus gallus)
Phosphorylation of SHC1 (Mus musculus)
Phosphorylation of SHC1 (Rattus norvegicus)
Phosphorylation of SHC1 (Sus scrofa)
Phosphorylation of SHC1 (Xenopus tropicalis)
Created
Bevan, AP  (2003-07-31)
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