Insulin receptor signalling cascade

Stable Identifier
R-HSA-74751
DOI
10.3180/REACT_1195.4
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Insulin receptor signalling cascade
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Autophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the autophosphorylation of the insulin receptor is its internalisation into an endosome, which downregulates its signalling activity.
Literature References
PubMed ID Title Journal Year
11282018 Insulin signalling.

Bevan, P

J Cell Sci 2001
9677303 Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.

Shepherd, PR, Siddle, K, Withers, DJ

Biochem J 1998
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Orthologous Events
Insulin receptor signalling cascade (Bos taurus)
Insulin receptor signalling cascade (Caenorhabditis elegans)
Insulin receptor signalling cascade (Canis familiaris)
Insulin receptor signalling cascade (Danio rerio)
Insulin receptor signalling cascade (Dictyostelium discoideum)
Insulin receptor signalling cascade (Drosophila melanogaster)
Insulin receptor signalling cascade (Gallus gallus)
Insulin receptor signalling cascade (Mus musculus)
Insulin receptor signalling cascade (Plasmodium falciparum)
Insulin receptor signalling cascade (Rattus norvegicus)
Insulin receptor signalling cascade (Saccharomyces cerevisiae)
Insulin receptor signalling cascade (Schizosaccharomyces pombe)
Insulin receptor signalling cascade (Sus scrofa)
Insulin receptor signalling cascade (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Bevan, AP  (2003-07-31)
Created
Bevan, AP  (2003-07-31)
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